Li Fei, Hu Shengda, Zhou Xianyong, Mei Xiaofei, Zhou Yafeng
Department of Cardiology, The First Affiliated Hospital of Soochow University.
Int Heart J. 2020 Jul 30;61(4):641-650. doi: 10.1536/ihj.19-219. Epub 2020 Jul 18.
A number of studies have showed the relationship between R353Q (rs6046) polymorphism in factor VII gene and coronary heart disease (CHD). However, the results remain controversial due to the limitations of the research objects and small sample size of individual study. We conducted this meta-analysis to validate the association between R353Q (rs6046) polymorphism and the risk of CHD.The relevant data was collected up to March 25, 2019 from PubMed, Web of Science, CNKI, and Wanfang databases. We examined all eligible studies using the Newcastle-Ottawa Quality Assessment Scale (NOS). The odds ratio (OR) and its corresponding 95% confidence interval (CI) were adopted to evaluate the relationship between the R353Q (rs6046) polymorphism and CHD. Stata version 14.0 (Stata Corporation, USA) was used in all statistical tests.There were at least 28 eligible studies, including 14626 cases and 17994 controls, included in our meta-analysis. R353Q (rs6046) polymorphism was associated with the reduced risk of CHD in four genetic models: allele model (Q versus R: OR = 0.79, 95% CI: 0.69 to 0.90, P < 0.001, I = 56.4%), homozygote (co-dominant) model (QQ versus RR: OR = 0.72, 95% CI = 0.58 to 0.92, P = 0.004, I = 5.8%), heterozygote (co-dominant) model (RQ versus RR: OR = 0.71, 95% CI = 0.58 to 0.86, P = 0.001, I = 75.4%), and dominant model (RQ+QQ versus RR: OR = 0.74, 95% CI = 0.63 to 0.865, P < 0.001, I = 64.1%) excluding recessive model (QQ versus RR+RQ: OR = 0.86, 95% CI = 0.57 to 1.28, P = 0.447, I = 51.6%).The results of the current meta-analysis suggested that R353Q (rs6046) polymorphism was associated with the reduced risk of CHD, especially in Asians.
多项研究表明，凝血因子VII基因中的R353Q（rs6046）多态性与冠心病（CHD）之间存在关联。然而，由于研究对象的局限性和个别研究样本量较小，结果仍存在争议。我们进行了这项荟萃分析，以验证R353Q（rs6046）多态性与冠心病风险之间的关联。截至2019年3月25日，从PubMed、Web of Science、中国知网和万方数据库收集了相关数据。我们使用纽卡斯尔-渥太华质量评估量表（NOS）对所有符合条件的研究进行了评估。采用比值比（OR）及其相应的95%置信区间（CI）来评估R353Q（rs6046）多态性与冠心病之间的关系。所有统计检验均使用Stata 14.0版本（美国Stata公司）。我们的荟萃分析纳入了至少28项符合条件的研究，包括14626例病例和17994例对照。在四种遗传模型中，R353Q（rs6046）多态性与冠心病风险降低相关：等位基因模型（Q与R：OR = 0.79，95%CI：0.69至0.90，P < 0.001，I = 56.4%），纯合子（共显性）模型（QQ与RR：OR = 0.72，95%CI = 0.58至0.92，P = 0.004，I = 5.8%），杂合子（共显性）模型（RQ与RR：OR = 0.71，95%CI = 0.58至0.86，P = 0.001，I = 75.4%），显性模型（RQ + QQ与RR：OR = 0.74，95%CI = 0.63至0.865，P < 0.001，I = 64.1%），不包括隐性模型（QQ与RR + RQ：OR = 0.86，95%CI = 0.57至1.28，P = 0.447，I = 51.6%）。当前荟萃分析的结果表明，R353Q（rs6046）多态性与冠心病风险降低相关，尤其是在亚洲人中。
