College of Veterinary Medicine, Sichuan Agricultural University, Ya'an, 625014, China.
Leshan City, Shizhong District of Animal Husbandry Bureau, Leshan, 614000, China.
Biol Trace Elem Res. 2021 Nov;199(11):4260-4272. doi: 10.1007/s12011-020-02558-1. Epub 2021 Jan 2.
This study aimed to determine the effects of selenium on the immune toxicity of subacute arsenic poisoning in chickens. Two hundred 8-day-old broilers were randomly divided into 5 groups: the control group (0.1 mg/kg As + 0.2 mg/kg Se), the As group (3 mg/kg As + 0.2 mg/kg Se), As + Se group I (3 mg/kg As + 5 mg/kg Se), As + Se group II (3 mg/kg As + 10 mg/kg Se), and As + Se group III (3 mg/kg As + 15 mg/kg Se). The conclusions were drawn based on the following measurements: 3.0 mg/kg added to feed led to a decrease in the growth performance of the broilers, reduced the level and conversion rate of ANAE, reduced the blood protein content of the broilers but had no effect on the albumin/globulin ratio, and had an inhibitory effect on erythrocyte immunity. Selenium-added of 5 and 10 mg/kg in daily feed leads to increased growth performance, increases the positive rate and conversion rate of ANAE, increases the hemoglobin content of broilers, and promotes erythrocyte immunity, which indicates that the selenium-added reduces the toxic effects of arsenic; 3.0 mg/kg arsenic with 15 mg/kg selenium had the most severe toxic effects. Fifteen milligrams per kilogram of selenium added in daily feed increases the toxicity of arsenic to broilers. The dose of 10 mg/kg selenium showed the best inhibitory effect on subacute arsenic poisoning in the broilers.
本研究旨在确定硒对亚急性砷中毒鸡免疫毒性的影响。将 200 只 8 日龄肉鸡随机分为 5 组：对照组（0.1mg/kgAs+0.2mg/kgSe）、砷组（3mg/kgAs+0.2mg/kgSe）、As+Se 组 I（3mg/kgAs+5mg/kgSe）、As+Se 组 II（3mg/kgAs+10mg/kgSe）和 As+Se 组 III（3mg/kgAs+15mg/kgSe）。根据以下测量结果得出结论：饲料中添加 3.0mg/kg 导致肉鸡生长性能下降，ANAE 水平和转化率降低，肉鸡血液蛋白含量降低，但白蛋白/球蛋白比值无影响，对红细胞免疫有抑制作用。饲料中每天添加 5 和 10mg/kg 的硒可提高生长性能，增加 ANAE 的阳性率和转化率，提高肉鸡血红蛋白含量，促进红细胞免疫，表明硒可降低砷的毒性；饲料中添加 3.0mg/kg 砷和 15mg/kg 硒的毒性最大。饲料中每天添加 15mg/kg 硒会增加砷对肉鸡的毒性。饲料中添加 10mg/kg 硒对肉鸡亚急性砷中毒的抑制作用最佳。
