Department of Marine Biology, Faculty of Marine Science and Technology, University of Hormozgan, Bandar Abbas, Iran.
Department of Microbiology, University of Karachi, Karachi 75270, Pakistan.
Int J Biol Macromol. 2021 Feb 15;170:674-687. doi: 10.1016/j.ijbiomac.2020.12.134. Epub 2020 Dec 30.
Marine organisms are rich sources of enzymes and their inhibitors having enormous therapeutic potential. Among different proteolytic enzymes, serine proteases, which can be obtained from various marine organisms show a potential to biomedical application as thrombolytic agents. Although this type of proteases plays a crucial role in almost all biological processes, their uncontrolled activity often leads to several diseases. Accordingly, the actions of these types of proteases are regulated by serine protease inhibitors (SPIs). Marine SPIs control complement activation and various other physiological functions, such as inflammation, immune function, fibrinolysis, blood clotting, and cancer metastasis. This review highlights the potential use of serine proteases and their inhibitors as the new wave of promising drugs.
海洋生物是酶及其抑制剂的丰富来源，具有巨大的治疗潜力。在不同的蛋白水解酶中，丝氨酸蛋白酶可以从各种海洋生物中获得，作为溶栓剂具有潜在的生物医学应用。尽管这类蛋白酶在几乎所有的生物过程中都起着至关重要的作用，但它们的活性失控往往会导致多种疾病。因此，这类蛋白酶的作用受到丝氨酸蛋白酶抑制剂（SPIs）的调节。海洋 SPIs 控制补体激活和其他各种生理功能，如炎症、免疫功能、纤维蛋白溶解、凝血和癌症转移。本综述强调了丝氨酸蛋白酶及其抑制剂作为有前途的新药的潜在用途。
