Kansas State University, USA.
Kansas State University, USA.
Psychiatry Res. 2021 Feb;296:113696. doi: 10.1016/j.psychres.2020.113696. Epub 2020 Dec 29.
Eye Movement Desensitization and Reprocessing (EMDR) has demonstrated efficacy in treating major depressive disorder. EMDR increases cerebral perfusion in the anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex (dlPFC). Activity in the ACC and dlPFC can be measured by theta cordance (TC) but has not been examined in EMDR. Ten participants (3 men, 7 women, M age = 42.31 ± 15.03) received ten 75 ± 15 minute EMDR sessions over 6.5 ± .5 weeks. Results indicated that PHQ-9 depression scores reduced from T1 (M = 13.9 ± 3.31) to T11 (M = 6.30 ± 3.23) with EMDR (SMD = 2.30), and that fTC but not pfTC was significantly related to this change. Depression declined as fTC declined. EMDR may engage the dlPFC or ACC that modulates depression and aid in reducing fTC and thus depression levels.
眼动脱敏再处理（EMDR）已被证明对治疗重度抑郁症有效。EMDR 增加了前扣带皮层（ACC）和背外侧前额叶皮层（dlPFC）的脑灌注。ACC 和 dlPFC 的活动可以通过θ协调（TC）来测量，但在 EMDR 中尚未进行检查。10 名参与者（3 名男性，7 名女性，M 年龄= 42.31 ± 15.03）在 6.5 ±.5 周内接受了 10 次 75 ± 15 分钟的 EMDR 治疗。结果表明，EMDR 治疗后 PHQ-9 抑郁评分从 T1（M = 13.9 ± 3.31）降至 T11（M = 6.30 ± 3.23）（SMD = 2.30），并且 fTC 而非 pfTC 与这种变化显著相关。抑郁随着 fTC 的降低而下降。EMDR 可能会激活调节抑郁的 dlPFC 或 ACC，并有助于降低 fTC，从而降低抑郁水平。
