Department of Clinical Pharmacy and Pharmacy Management, University of Nigeria, Nsukka, Enugu State, Nigeria; Pharmacoeconomics and Mental Health Research Group, University of Nigeria, Nsukka, Enugu State, Nigeria.
Department of Clinical Pharmacy and Pharmacy Management, University of Nigeria, Nsukka, Enugu State, Nigeria.
Value Health Reg Issues. 2021 Sep;25:1-6. doi: 10.1016/j.vhri.2020.09.002. Epub 2020 Dec 30.
Globally, an appropriate estimate of the health-related quality of life (HRQoL) of people living with HIV/AIDS (PLWHA) is essential for the economic evaluation of antiretroviral therapy (ART) programs to ensure optimal value for money. Therefore, this article aimed to evaluate the HRQoL of PLWHA on ART and to explore its predictors.
A cross-sectional study was conducted among PLWHA in an ART clinic of a Nigerian tertiary hospital. The participants were selected through a computer-based simple random sampling technique. The study instrument used for data collection was the English-language version of the European Quality of Life (EQ-5D-5L). The participants completed the questionnaire in the waiting room of the clinic, and the patients' clinical data were retrieved from their medical records. Descriptive statistics and multivariate linear regression were used for data analysis. P<.05 was considered statistically significant.
Out of the 352 participants, the majority were female (66.5%), and more than half (56.2%) had a CD4 count fewer than 500 cells/mm. The EQ-5D index and utility score of the study population were 0.72 ± 4.18 and 73.05 ± 10.36, respectively. The significant predictors of EQ-5D index were the number of children (β = -0.215, P=.026), CD4 count (β = 0.171, P=.030), and duration on ART (β = -0.144, P=.011).
Our findings suggest that PLWHA receiving ART in Nigeria had good HRQoL. However, concerted efforts targeted at improving CD4 cell count and reducing the family burden of PLWHA would enhance their HRQoL.
在全球范围内，对艾滋病毒/艾滋病感染者（PLWHA）的健康相关生活质量（HRQoL）进行适当估计对于评估抗逆转录病毒疗法（ART）方案的经济价值至关重要，以确保物有所值。因此，本文旨在评估接受 ART 的 PLWHA 的 HRQoL，并探讨其预测因素。
本研究为在尼日利亚一家三级医院的 ART 诊所进行的横断面研究。采用基于计算机的简单随机抽样技术选择参与者。用于数据收集的研究工具是欧洲生活质量问卷（EQ-5D-5L）的英文版本。参与者在诊所的候诊室完成问卷，从他们的病历中检索患者的临床数据。采用描述性统计和多元线性回归进行数据分析。P<.05 被认为具有统计学意义。
在 352 名参与者中，大多数是女性（66.5%），超过一半（56.2%）的 CD4 计数少于 500 个细胞/mm³。研究人群的 EQ-5D 指数和效用评分分别为 0.72 ± 4.18 和 73.05 ± 10.36。EQ-5D 指数的显著预测因素是儿童数量（β=-0.215，P=.026）、CD4 计数（β=0.171，P=.030）和接受 ART 的时间（β=-0.144，P=.011）。
我们的研究结果表明，在尼日利亚接受 ART 的 PLWHA 具有良好的 HRQoL。然而，有针对性地努力改善 CD4 细胞计数并减轻 PLWHA 的家庭负担将提高他们的 HRQoL。
