评估埃塞俄比亚与健康相关的生活质量：基于EQ-5D研究的系统评价和荟萃分析。
Evaluating health-related quality of life in Ethiopia: systematic review and meta-analysis of EQ-5D-based studies.
作者信息
Tarekegn Tenaw Baye, Gebrie Desye, Kassaw Abebe Tarekegn, Dagne Taye Abebe, Girmaw Fentaw, Ashagrie Getachew
机构信息
Department of Pharmacy, College of Health Science, Woldia University, Woldia, Ethiopia.
Department of Pharmacy, College of Health Science, Debre Markos University, Debre Markos, Ethiopia.
出版信息
Front Epidemiol. 2024 Nov 1;4:1455822. doi: 10.3389/fepid.2024.1455822. eCollection 2024.
BACKGROUND
Health-related quality of life (HRQoL) is crucial for understanding how health conditions impact overall well-being. The EuroQol-5 Dimension (EQ-5D) is a widely used tool for measuring HRQoL across diseases. In Ethiopia, this tool has been employed to assess HRQoL across various healthcare settings. This study aims to summarize EQ-5D-derived health outcomes in Ethiopian populations and identify key determinants influencing these outcomes.
METHODS
A systematic search of PubMed, Embase, and Scopus was conducted through May 2024, with no publication date restrictions, focusing on HRQoL and EQ-5D instruments in Ethiopian populations. Grey literature searches were also performed using Google's Advanced Search. Cross-sectional studies across various diseases were included. Data were extracted by two independent reviewers, and pooled mean EQ-5D utility and EQ-5D visual analog scale (EQ-VAS) scores were calculated using a random-effects model in STATA software version 17. Study quality was evaluated using the Agency for Healthcare Research and Quality (AHRQ) checklist, and heterogeneity was assessed using the ² statistic.
RESULTS
Fourteen cross-sectional studies involving 5,639 patients from 2019 to 2024 in Ethiopia were analyzed. Health utility values varied across diseases, with pain/discomfort and anxiety/depression being the most commonly affected dimensions. The pooled EQ-5D utility for HIV patients was 0.88, and the EQ-VAS score was 76.59. For diabetes mellitus (DM) patients, the pooled utility was 0.78, and the EQ-VAS score was 69.36. For COVID-19 patients, the pooled utility was 0.86, and the EQ-VAS score was 74.56. Cancer patients had a pooled EQ-VAS score of 67.87.
CONCLUSION
The EQ-5D is a reliable tool for measuring HRQoL in Ethiopian patients across various diseases. The study's pooled EQ-5D scores provide valuable insights for future economic evaluations in the Ethiopian healthcare system.
SYSTEMATIC REVIEW REGISTRATION
https://doi.org/10.1136/bmjopen-2024-085354, PROSPERO (CRD42024505028).
背景
健康相关生活质量（HRQoL）对于理解健康状况如何影响整体幸福感至关重要。欧洲五维健康量表（EQ - 5D）是一种广泛用于测量各种疾病患者HRQoL的工具。在埃塞俄比亚，该工具已被用于评估不同医疗环境下的HRQoL。本研究旨在总结埃塞俄比亚人群中由EQ - 5D得出的健康结果，并确定影响这些结果的关键决定因素。
方法
截至2024年5月，对PubMed、Embase和Scopus进行了系统检索，无出版日期限制，重点关注埃塞俄比亚人群中的HRQoL和EQ - 5D工具。还使用谷歌高级搜索进行了灰色文献检索。纳入了各种疾病的横断面研究。由两名独立评审员提取数据，并使用STATA软件版本17中的随机效应模型计算合并的EQ - 5D效用值和EQ - 5D视觉模拟量表（EQ - VAS）得分。使用医疗保健研究与质量局（AHRQ）清单评估研究质量，并使用I²统计量评估异质性。
结果
分析了2019年至2024年在埃塞俄比亚进行涉及5639名患者的14项横断面研究。不同疾病的健康效用值各不相同，疼痛/不适和焦虑/抑郁是最常受影响的维度。HIV患者的合并EQ - 5D效用值为0.88，EQ - VAS得分为76.59。糖尿病（DM）患者的合并效用值为0.78，EQ - VAS得分为69.36。COVID - 19患者的合并效用值为0.86，EQ - VAS得分为74.56。癌症患者的合并EQ - VAS得分为67.87。
结论
EQ - 5D是测量埃塞俄比亚不同疾病患者HRQoL的可靠工具。该研究的合并EQ - 5D得分可为埃塞俄比亚医疗保健系统未来的经济评估提供有价值的见解。
系统评价注册
https://doi.org/10.1136/bmjopen - 2024 - 085354，PROSPERO（CRD42024505028）。
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