转化生长因子-β信号传导与微小RNA相互作用调控腹主动脉瘤进展。
TGF-β signaling and microRNA cross-talk regulates abdominal aortic aneurysm progression.
作者信息
Tang Ying, Fan Wenjing, Zou Bu, Yan Wei, Hou Yangfeng, Kwabena Agyare Oware, Jiang Zhisheng, Qu Shunlin
机构信息
Pathophysiology Department, Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, University of South China, Hengyang, Hunan 421001, PR China; Clinic Department, Hengyang Medical College, University of South China, Hengyang 421001, PR China.
Pathophysiology Department, Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, University of South China, Hengyang, Hunan 421001, PR China; Emergency Department, The Second Affiliated Hospital, University of South China, Hengyang City, Hunan Province 421001, PR China.
出版信息
Clin Chim Acta. 2021 Apr;515:90-95. doi: 10.1016/j.cca.2020.12.031. Epub 2020 Dec 31.
Abdominal aortic aneurysms (AAA) are permanent and irreversible local dilatations of the abdominal aortic wall. Recent data indicate that the transforming growth factor-beta (TGF-β) signaling pathway exerts a protective effect on the development of AAA. Some dysregulated microRNAs (miRNA) also appear involved in the expansion of AAA and miRNA-based therapeutics have been shown to effectively inhibit this process. New evidence has revealed that TGF-β signaling and miRNA interaction may of physiologic and pathophysiologic significance including the progression of AAA. As such, miRNA that regulate TGF-β signaling may hold promise as potential therapeutic targets. This review explores potential crosstalk between TGF-β signaling and miRNA in AAA in order improve our understanding of this pathology and explore development of potential therapeutic targets.
腹主动脉瘤（AAA）是腹主动脉壁的永久性和不可逆性局部扩张。近期数据表明，转化生长因子-β（TGF-β）信号通路对腹主动脉瘤的发展具有保护作用。一些失调的微小RNA（miRNA）似乎也参与了腹主动脉瘤的扩张，并且基于miRNA的治疗已被证明可有效抑制这一过程。新证据显示，TGF-β信号传导与miRNA相互作用可能具有生理和病理生理意义，包括腹主动脉瘤的进展。因此，调节TGF-β信号传导的miRNA有望成为潜在的治疗靶点。本综述探讨了腹主动脉瘤中TGF-β信号传导与miRNA之间的潜在相互作用，以增进我们对这种病理学的理解，并探索潜在治疗靶点的开发。
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