Lagente V, Cirino M, Desquand S, Lefort J, Vargaftig B B
Unité associée Institut Pasteur/INSERM U285, Paris, France.
Int Arch Allergy Appl Immunol. 1988;85(1):14-9. doi: 10.1159/000234469.
Bronchoconstriction following the aerosolization of PAF-acether or antigen to guinea pigs induces autodesensitization, but the responses to direct spasmogenic substances are not modified. Bronchoconstriction by PAF-acether is not reduced when it is aerosolized to passively sensitized animals previously desensitized by repeated inhalations of the allergen (ovalbumin). In contrast, when passively sensitized animals are initially desensitized to PAF-acether by repeated inhalations of this agonist, ovalbumin aerosolization induces a bronchoconstriction which is significantly reduced when compared with the response obtained in nondesensitized animals though, in this case, the response to aerosolized histamine is not modified. Thus, PAF-acether is released during intrapulmonary anaphylactic shock induced by aerosolized ovalbumin and can be a prime candidate for its development.
将PAF-乙醚或抗原雾化给豚鼠后引起的支气管收缩会诱导自身脱敏，但对直接致痉物质的反应并未改变。当将PAF-乙醚雾化给先前经反复吸入变应原（卵清蛋白）脱敏的被动致敏动物时，PAF-乙醚引起的支气管收缩并未减轻。相反，当通过反复吸入该激动剂使被动致敏动物最初对PAF-乙醚脱敏时，卵清蛋白雾化会诱导支气管收缩，与未脱敏动物所获得的反应相比，该收缩明显减轻，不过在这种情况下，对雾化组胺的反应并未改变。因此，在雾化卵清蛋白诱导的肺内过敏性休克期间会释放PAF-乙醚，它可能是其发展的主要候选物质。
