一项关于BN 52021的研究表明血小板活化因子（PAF-乙酰醚）参与了IgE依赖性过敏性支气管收缩。

A study with BN 52021 demonstrates the involvement of PAF-acether in IgE-dependent anaphylactic bronchoconstriction.

作者信息

Cirino M, Lagente V, Lefort J, Vargaftig B B

出版信息

Prostaglandins. 1986 Jul;32(1):121-6. doi: 10.1016/0090-6980(86)90153-x.

Abstract

The involvement of platelet activating factor (PAF) in anaphylaxis was examined by recording the pulmonary responses of anesthetized passively sensitized guinea-pigs to the aerosolization of ovalbumin. Animals were tested with and without BN 52021 (a ginkgolide B, PAF receptor antagonist) pretreatment. Aerosolization of ovalbumin produced a bronchoconstriction (BC) which could be made refractory to additional challenges with the antigen. In animals desensitized to ovalbumin, aerosolization of PAF produced an unattenuated BC. Guinea pigs desensitized by repeated aerosolizations of PAF subsequently showed reduced responses to aerosolized antigen suggesting that PAF may be involved in the BC. Animals pretreated with BN 52021, were protected against the effects of systemically administered PAF and also showed reduced responses to aerosolized antigen. Aerosolization of the leukotriene antagonist, FPL 55712, was ineffective against anaphylactic BC under conditions where catecholamine and histamine release were blocked.

摘要

通过记录麻醉的被动致敏豚鼠对雾化卵清蛋白的肺部反应，研究了血小板活化因子（PAF）在过敏反应中的作用。对动物进行了有无BN 52021（一种银杏内酯B，PAF受体拮抗剂）预处理的测试。雾化卵清蛋白会引起支气管收缩（BC），并且该收缩会对抗原的额外刺激产生不应性。在对卵清蛋白脱敏的动物中，雾化PAF会产生未减弱的BC。通过反复雾化PAF脱敏的豚鼠随后对雾化抗原的反应降低，这表明PAF可能参与了BC。用BN 52021预处理的动物对全身给药的PAF的作用具有抵抗力，并且对雾化抗原的反应也降低。在儿茶酚胺和组胺释放被阻断的条件下，白三烯拮抗剂FPL 55712的雾化对过敏性BC无效。