Key Laboratory of Big Data Mining and Precision Drug Design of Guangdong Medical University, Key Laboratory for Research and Development of Natural Drugs of Guangdong Province, School of Pharmacy, Guangdong Medical University, No. 1 Xincheng Road, Dongguan, 523808, Guangdong, China.
Marine Medical Research Institute of Guangdong Zhanjiang, Zhanjiang, 524023, Guangdong, China.
J Cancer Res Clin Oncol. 2021 Jan;147(1):3-22. doi: 10.1007/s00432-020-03460-y. Epub 2021 Jan 3.
This paper reviews marine compounds that target the mitogen-activated protein kinase (MAPK) signaling pathway and their main sources, chemical structures, major targeted cancers and possible mechanisms to provide comprehensive and basic information for the development of marine compound-based antitumor drugs in clinical cancer therapy research.
This paper searched the PubMed database using the keywords "cancer", "marine*" and "MAPK signaling pathway"; this search was supplemented by the literature-tracing method. The marine compounds screened for review in this paper are pure compounds with a chemical structure and have antitumor effects on more than one tumor cell line by targeting the MAPK signaling pathway. The PubChem database was used to search for the PubMed CID and draw the chemical structures of the marine compounds.
A total of 128 studies were searched, and 32 marine compounds with unique structures from extensive sources were collected for this review. These compounds are cytotoxic to cancer cell lines, although their targets are still unclear. This paper describes their anticancer effect mechanisms and the protein expression changes in the MAPK pathway induced by these marine compound treatments. This review is the first to highlight MAPK signaling pathway-targeted marine compounds and their use in cancer therapy.
The MAPK signaling pathway is a promising potential target for cancer therapy. Searching for marine compounds that exert anticancer effects by targeting the MAPK signaling pathway and developing them into new marine anticancer drugs will be beneficial for cancer treatment.
本文综述了靶向丝裂原活化蛋白激酶（MAPK）信号通路的海洋化合物及其主要来源、化学结构、主要靶向癌症及可能的作用机制，为临床癌症治疗研究中基于海洋化合物的抗肿瘤药物开发提供全面和基础的信息。
本文通过关键词“癌症”、“海洋*”和“MAPK 信号通路”在 PubMed 数据库中进行检索，并通过文献追溯法进行补充。本文筛选出的海洋化合物为具有化学结构的纯化合物，通过靶向 MAPK 信号通路对一种以上肿瘤细胞系具有抗肿瘤作用。使用 PubChem 数据库搜索 PubMed CID，并绘制海洋化合物的化学结构。
共检索到 128 项研究，收集了来自广泛来源的 32 种具有独特结构的海洋化合物进行综述。这些化合物对癌细胞系具有细胞毒性，但它们的靶点仍不清楚。本文描述了它们的抗癌作用机制以及这些海洋化合物处理诱导的 MAPK 通路中蛋白表达的变化。这是首次强调靶向 MAPK 信号通路的海洋化合物及其在癌症治疗中的应用。
MAPK 信号通路是癌症治疗的一个有前途的潜在靶点。寻找通过靶向 MAPK 信号通路发挥抗癌作用的海洋化合物，并将其开发成新型海洋抗癌药物，将有益于癌症治疗。
