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COVID-19 的眼部表现:一个虽不常见但意义重大的挑战。

Ophthalmic manifestations of COVID-19; a less-appreciated yet significant challenge.

机构信息

Department of Ophthalmology, Poostchi Ophthalmology Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Farvardin Eye Clinic, Shiraz, Iran.

出版信息

Int Ophthalmol. 2021 Mar;41(3):1141-1147. doi: 10.1007/s10792-020-01664-2. Epub 2021 Jan 2.

DOI:10.1007/s10792-020-01664-2
PMID:33389366
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7778483/
Abstract

AIM

The current world has changed in all shapes since the emergence of the novel coronavirus (nCoV-2) also known as COVID-19. Among the extra-pulmonary manifestations of nCoV-2, ophthalmic symptoms have less been systematically studied. The so far existing body of evidence indicates that nCoV-2 has the potential to affect both anterior and posterior chambers of the eye. Albeit, the exact mechanisms which underlie ophthalmic manifestations of nCoV-2 are yet to be elucidated.

METHODS

The present brief review is an attempt to put together and highlight the significant yet limited number of studies which have spotlighted ophthalmic issues in nCoV-2 patients using a systematic literature search strategy.

RESULTS

All case series or reports (including both published and preprint articles) which described ocular manifestations of patients with COVID-19 and/or documented testing of SARS-COV-2 in ocular secretions via various sampling or detection methods were sought to be included.

CONCLUSION

The ophthalmic presentations in SARS-COV-2 are often found to be salient. Raising awareness in this respect may help defining evidencebased protective measures in today's practice of ophthalmology and allied disciplines.

摘要

目的

自新型冠状病毒(nCoV-2)又称 COVID-19 出现以来,当前的世界已经发生了全面的变化。在 nCoV-2 的肺外表现中,眼科症状较少被系统研究。到目前为止,现有证据表明 nCoV-2 有可能影响眼睛的前房和后房。尽管如此,nCoV-2 引起眼科表现的确切机制仍有待阐明。

方法

本简要综述试图通过系统的文献检索策略,将目前已有的为数不多的、重点关注 nCoV-2 患者眼科问题的研究进行汇总和强调。

结果

所有描述 COVID-19 患者眼部表现的病例系列或报告(包括已发表和预印本文章),以及通过各种采样或检测方法记录 SARS-COV-2 在眼部分泌物中的检测结果的研究,都被纳入考虑范围。

结论

在 SARS-COV-2 中,眼部表现通常很明显。在这方面提高认识可能有助于在当今的眼科及相关学科实践中确定基于证据的保护措施。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d89/7778483/61171a8f39fe/10792_2020_1664_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d89/7778483/61171a8f39fe/10792_2020_1664_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d89/7778483/61171a8f39fe/10792_2020_1664_Fig1_HTML.jpg

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JAMA Ophthalmol. 2020 Oct 1;138(10):1079-1086. doi: 10.1001/jamaophthalmol.2020.3690.
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Concerns about the interpretation of OCT and fundus findings in COVID-19 patients in recent Lancet publication.近期《柳叶刀》发表的文章对新冠病毒肺炎患者光学相干断层扫描(OCT)及眼底检查结果的解读提出了担忧。
Eye (Lond). 2020 Dec;34(12):2153-2154. doi: 10.1038/s41433-020-1084-9. Epub 2020 Jul 9.
3
SARS-COV-2 and eye immunity: the lesson was learned but we are not done yet. Brainstorming on possible pathophysiology inspired by ocular models.
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Int Ophthalmol. 2020 Aug;40(8):1879-1883. doi: 10.1007/s10792-020-01495-1.
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Retinal findings in patients with COVID-19.新型冠状病毒肺炎患者的视网膜病变
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