Zhao Yun-Li, Gou Zhong-Ping, Shang Jian-Hua, Li Wan-Yi, Kuang Yu, Li Ming-Yuan, Luo Xiao-Dong
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Chemical Science and Technology, Yunnan University, Kunming, 650091, P. R. China.
Nat Prod Bioprospect. 2021 Feb;11(1):127-135. doi: 10.1007/s13659-020-00294-6. Epub 2021 Jan 3.
Alstonia scholaris could be used as a traditional medicinal plant in China for the treatment of acute respiratory, which might be caused by respiratory tract infections. The investigation tested the anti-infective effects of total alkaloids extract (TA) from leaves of A. scholaris, and as a result, TA inhibited herpes simplex virus type 1 (HSV-1), respiratory syncytial virus (RSV) and influenza A virus (H1N1) in vitro respectively. In addition, the survival days of mice were prolonged, and the lung weights and mortality of mice were decreased significantly, after oral administrated TA in H1N1 and beta-hemolytic streptococcus infectious models in vivo respectively. The finding supported partly the traditional usage of A. scholaris in the treatment of respiratory infections.
印度萝芙木在中国可作为传统药用植物用于治疗急性呼吸道疾病，这些疾病可能由呼吸道感染引起。该研究测试了印度萝芙木叶总生物碱提取物（TA）的抗感染作用，结果表明，TA在体外分别抑制了1型单纯疱疹病毒（HSV-1）、呼吸道合胞病毒（RSV）和甲型流感病毒（H1N1）。此外，在体内H1N1和β-溶血性链球菌感染模型中分别口服TA后，小鼠的存活天数延长，肺重量和死亡率显著降低。这一发现部分支持了印度萝芙木在治疗呼吸道感染方面的传统用途。
