Kamian Shaghayegh, Ebrahimi Abdolali, Zadeh Kaveh Ebrahim, Behzadi Behnaz
Department of Radiotherapy Oncology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Pathology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Radiat Oncol J. 2020 Dec;38(4):282-286. doi: 10.3857/roj.2020.00577. Epub 2020 Dec 2.
Primary intracranial mesenchymal neoplasms are rare tumors. These tumors are usually metastatic disease from other primary sites. We presented a 31-year-old man with a 6-month history of gradually enlarging frontal mass and positional headache. There was no other symptom demonstrating other organs' involvement. The patient underwent an uncomplicated craniotomy with clear surgical margins. The pathology review and the immunohistochemistry staining confirmed leiomyosarcoma grade II. We prescribed radiation therapy with tumor dose of 60 Gy in 30 fractions with conformal treatment planning to the tumor bed. As this disease has a high potency for metastasis, we advised four courses of single agent doxorubicin chemotherapy 75 mg/m2 every 4 weeks starting one month after the end of radiotherapy. In the last follow-up visit 34 months later, the patient was disease free in physical exam and imaging findings.
原发性颅内间叶性肿瘤是罕见肿瘤。这些肿瘤通常是其他原发部位的转移性疾病。我们报告了一名31岁男性，有6个月逐渐增大的额叶肿块及体位性头痛病史。没有其他症状提示其他器官受累。患者接受了一次手术顺利的开颅手术，手术切缘清晰。病理检查及免疫组化染色确诊为II级平滑肌肉瘤。我们采用适形治疗计划对瘤床进行放射治疗，肿瘤剂量为60 Gy，分30次给予。由于这种疾病有很高的转移潜能，我们建议在放疗结束后1个月开始，每4周进行4个疗程的单药阿霉素化疗，剂量为75 mg/m²。在34个月后的最后一次随访中，患者体格检查及影像学检查均未发现疾病迹象。
