Physiotherapy Department, Le Havre Hospital, Montivilliers, France.
Institut De Recherche Et d'Expérimentation Clinique (IREC), Pôle De Pneumologie, ORL and Dermatologie, Université Catholique De Louvain, Brussels, Belgium.
Physiother Theory Pract. 2022 Oct;38(10):1389-1397. doi: 10.1080/09593985.2020.1868029. Epub 2021 Jan 4.
Oxygen uptake (V̇O) kinetics have been shown to be slowed in adolescents with cystic fibrosis (CF) during heavy-intensity cycling and maximal exercise testing.
This study investigated V̇O kinetics in adolescents with CF compared to control adolescents (CON) during a treadmill-walking exercise.
Eight adolescents with CF and mild-to-moderate pulmonary obstruction (5 girls; 13.1 ± 2.5 years; FEV 67.8 ± 21.4%) and 18 CON adolescents (10 girls; 13.8 ± 1.8 years) were recruited. Pulmonary gas exchange and ventilation were measured during a single transition of 10 min of treadmill walking and a 5 min seated recovery period. Participant's walking speed was determined during a one-minute self-paced walking task along a 50-m corridor. A six-parameter, non-linear regression model was used to describe the changes in V̇O function during the treadmill walking and recovery, with monoexponential curve fitting used to describe the mean response time (MRT) at the onset of exercise, and the half-life (TV̇O) at the offset of exercise. V̇O baseline and amplitude, minute ventilation and respiratory equivalents were recorded.
V̇O kinetics were slower in CF group compared to CON group during the treadmill walking with a greater MRT (32 ± 14 s vs 21 ± 16 s; = .04, effect size = 0.75). The TV̇O2 was prolonged during recovery in CF group compared to CON group (86 ± 24 s vs 56 ± 22 s; = .04, effect size = 1.31). The mean VE/V̇CO during exercise was the only parameter significantly greater in CF group compared to CON group (32.9 ± 2.3 vs 29.0 ± 2.4; < .01, effect size = 1.66).
V̇O kinetics were found to be slowed in adolescents with CF during treadmill walking.
在高强度的自行车运动和最大运动测试中，已经证明囊性纤维化 (CF) 青少年的氧气摄取量 (V̇O) 动力学减慢。
本研究比较了 CF 青少年和对照青少年 (CON) 在跑步机行走运动期间的 V̇O 动力学。
招募了 8 名患有轻度至中度肺阻塞的 CF 青少年（5 名女孩；13.1 ± 2.5 岁；FEV 67.8 ± 21.4%）和 18 名 CON 青少年（10 名女孩；13.8 ± 1.8 岁）。在跑步机行走 10 分钟和坐 5 分钟恢复期内测量肺部气体交换和通气。在沿着 50 米走廊进行一分钟的自我调节步行任务期间，确定参与者的步行速度。使用六参数非线性回归模型描述跑步机行走和恢复期间 V̇O 功能的变化，使用单指数曲线拟合来描述运动开始时的平均响应时间 (MRT)，以及运动结束时的半衰期 (TV̇O)。记录 V̇O 基线和振幅、分钟通气量和呼吸等价物。
与 CON 组相比，CF 组在跑步机行走期间的 V̇O 动力学较慢，MRT 更大（32 ± 14 秒与 21 ± 16 秒； = 0.04，效应量 = 0.75）。与 CON 组相比，CF 组在恢复期间的 TV̇O2 延长（86 ± 24 秒与 56 ± 22 秒； = 0.04，效应量 = 1.31）。与 CON 组相比，CF 组在运动期间的平均 VE/V̇CO 是唯一显著较大的参数（32.9 ± 2.3 与 29.0 ± 2.4； < 0.01，效应量 = 1.66）。
在跑步机行走期间，发现 CF 青少年的 V̇O 动力学减慢。
