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本文引用的文献

1
A Randomized Trial of High-Flow Oxygen Therapy in Infants with Bronchiolitis.随机对照试验:高流量氧疗在毛细支气管炎患儿中的应用
N Engl J Med. 2018 Mar 22;378(12):1121-1131. doi: 10.1056/NEJMoa1714855.
2
Humidified high-flow nasal cannula oxygen in bronchiolitis reduces need for invasive ventilation but not intensive care admission.毛细支气管炎中使用高流量湿化鼻导管吸氧可减少有创通气需求,但不能减少重症监护病房收治率。
J Paediatr Child Health. 2017 Sep;53(9):897-902. doi: 10.1111/jpc.13564. Epub 2017 May 23.
3
Paediatric high-flow nasal cannula therapy in children with bronchiolitis: A retrospective safety and efficacy study in a non-tertiary environment.小儿毛细支气管炎的高流量鼻导管治疗:非三级医疗机构环境下的回顾性安全性和疗效研究
Emerg Med Australas. 2017 Apr;29(2):198-203. doi: 10.1111/1742-6723.12741.
4
High-flow warm humidified oxygen versus standard low-flow nasal cannula oxygen for moderate bronchiolitis (HFWHO RCT): an open, phase 4, randomised controlled trial.高流量温湿氧疗对比标准低流量鼻导管氧疗治疗轻中度细支气管炎(HFWHO RCT):一项开放标签、4 期、随机对照试验。
Lancet. 2017 Mar 4;389(10072):930-939. doi: 10.1016/S0140-6736(17)30061-2. Epub 2017 Feb 2.
5
High flow nasal cannula use outside of the ICU; factors associated with failure.重症监护病房以外使用高流量鼻导管;与失败相关的因素。
Pediatr Pulmonol. 2017 Jun;52(6):806-812. doi: 10.1002/ppul.23626. Epub 2016 Nov 21.
6
High-flow oxygen therapy is more cost-effective for bronchiolitis than standard treatment-A decision-tree analysis.高流量氧疗治疗细支气管炎比标准治疗更具成本效益——一项决策树分析。
Pediatr Pulmonol. 2016 Dec;51(12):1393-1402. doi: 10.1002/ppul.23467. Epub 2016 May 5.
7
Using a high-flow nasal cannula provided superior results to low-flow oxygen delivery in moderate to severe bronchiolitis.在中度至重度细支气管炎中,使用高流量鼻导管给氧比低流量给氧效果更佳。
Acta Paediatr. 2016 Aug;105(8):e368-72. doi: 10.1111/apa.13444. Epub 2016 May 16.
8
Is there a role for humidified heated high-flow nasal cannula therapy in paediatric emergency departments?温热湿化高流量鼻导管治疗在儿科急诊科有作用吗?
Emerg Med J. 2016 Jun;33(6):386-9. doi: 10.1136/emermed-2015-204914. Epub 2016 Jan 4.
9
High-flow nasal cannula: recommendations for daily practice in pediatrics.高流量鼻导管:儿科日常实践建议。
Ann Intensive Care. 2014 Sep 30;4:29. doi: 10.1186/s13613-014-0029-5. eCollection 2014.
10
Use of high flow nasal cannula oxygen (HFNCO) in infants with bronchiolitis on a paediatric ward: a 3-year experience.在儿科病房对患细支气管炎的婴儿使用高流量鼻导管给氧(HFNCO):三年经验
Arch Dis Child. 2014 Aug;99(8):790-1. doi: 10.1136/archdischild-2014-306637. Epub 2014 Jun 17.

高流量鼻导管在社区儿科病房的应用及病情恶化的危险因素。

Uses of high-flow nasal cannula on the community paediatric ward and risk factors for deterioration.

作者信息

De Santis Diana, Sheriff Falana, Bester Deborah, Shahab Rabia, Hutzal Carolyn

机构信息

Michael G. DeGroote School of Medicine, McMaster University, Waterloo Regional Campus, Kitchener, Ontario.

Respiratory Therapy, Grand River Hospital, Kitchener, Ontario.

出版信息

Paediatr Child Health. 2020 Mar;25(2):102-106. doi: 10.1093/pch/pxy123. Epub 2019 Feb 11.

DOI:10.1093/pch/pxy123
PMID:33390747
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7757766/
Abstract

BACKGROUND

High-flow nasal cannula (HFNC) is a form of noninvasive respiratory support used for paediatric acute respiratory illnesses. Past HFNC research has focused on its use in bronchiolitis and in intensive care units, but little is reported on its use in the community hospital setting. We aimed to investigate the paediatric population using HFNC, any adverse events, and risk factors for deterioration.

METHODS

A retrospective chart review was performed on patients admitted to a community paediatric ward. Inclusion criteria were patients between 1 day and 17 years of age, admitted between September 2013 and April 2016, and treated with HFNC for at least 4 hours.

RESULTS

A total of 85 children met inclusion criteria. The average age of patients in our study was 3.41 years with 39% of patients >2 years of age. 46% of patients had an admitting diagnosis of bronchiolitis, 33% pneumonia, and 16% with asthma. Transfer rate to tertiary care centre paediatric intensive care unit was 18%. Patients transferred required greater FIO2 (odds ratio [OR] 1.04, P=0.018, confidence interval [CI] 1.007 to 1.082), and were 3.2 times more likely to be positive for respiratory syncytial virus (RSV) (P=0.081, CI 0.868-11.739). There were no adverse events attributed to HFNC in the population.

CONCLUSION

HFNC is being utilized in the community hospital setting for children of varied age and types of respiratory illnesses. Children requiring higher FIO2 are at risk of respiratory deterioration which may identify them earlier for transfer to tertiary care. Further research into the safety and efficacy of HFNC for different paediatric illnesses in the community is needed.

摘要

背景

高流量鼻导管(HFNC)是用于小儿急性呼吸道疾病的一种无创呼吸支持形式。既往关于HFNC的研究主要集中在其在细支气管炎和重症监护病房中的应用,但在社区医院环境中的应用报道较少。我们旨在调查使用HFNC的儿科人群、任何不良事件以及病情恶化的危险因素。

方法

对入住社区儿科病房的患者进行回顾性病历审查。纳入标准为年龄在1天至17岁之间、于2013年9月至2016年4月期间入院且接受HFNC治疗至少4小时的患者。

结果

共有85名儿童符合纳入标准。我们研究中患者的平均年龄为3.41岁,其中39%的患者年龄大于2岁。46%的患者入院诊断为细支气管炎,33%为肺炎,16%为哮喘。转至三级护理中心儿科重症监护病房的比例为18%。转院患者需要更高的吸入氧分数(FIO2)(比值比[OR]1.04,P = 0.018,置信区间[CI]1.007至1.082),呼吸道合胞病毒(RSV)检测呈阳性的可能性是其他患者的3.2倍(P = 0.081,CI 0.868 - 11.739)。该人群中未出现归因于HFNC的不良事件。

结论

社区医院环境中正在对不同年龄和各种呼吸道疾病类型的儿童使用HFNC。需要更高FIO2的儿童有呼吸恶化的风险,这可能有助于更早地识别他们以便转至三级护理。需要进一步研究HFNC在社区中针对不同儿科疾病的安全性和有效性。