Department of Emergency, E-Da Hospital, Kaohsiung 82445 Taiwan.
School of Medicine, College of Medicine, I-Shou University, Kaohsiung, 82445 Taiwan.
Int J Med Sci. 2021 Jan 1;18(1):1-7. doi: 10.7150/ijms.50646. eCollection 2021.
Chronic kidney disease (CKD) is a major risk factor for coronary artery disease and it is often associated with hepatic steatosis. Hepassocin (also known as hepatocyte-derived fibrinogen related protein or fibrinogen-like 1) is a novel hepatokine that causes hepatic steatosis and induces insulin resistance. However, the role of hepassocin in renal function status remains unclear. Our objective was to investigate the association of plasma hepassocin level with fatty liver and renal function status in patients with stable angina. Plasma hepassocin levels were determined by enzyme-linked immunosorbent assays in 395 consecutive patients with stable angina. Renal function was defined as an estimated glomerular filtration rate (eGFR). Fatty liver was defined by ultrasonography and fibrosis-4 (FIB-4) index. With increasing hepassocin tertiles, patients had higher prevalence of fatty live, an increased waist-to-hip ratio, and neutrophil count, monocyte count, and FIB-4 index, higher levels of uric acid, blood urine nitrogen and higher sensitivity C-reactive protein. They also had incrementally lower eGFR, serum hemoglobin and albumin levels. In multiple linear stepwise regression analysis, only eGFR was significantly independent negatively associated with plasma hepassocin levels. Our results indicate that circulating hepassocin in patients with stable angina is associated with fatty liver and renal function, which suggests that increased plasma hepassocin may be involved in the pathogenesis of fatty liver and CKD.
慢性肾脏病 (CKD) 是冠状动脉疾病的主要危险因素，常伴有肝脂肪变性。Hepassocin（也称为肝细胞衍生的纤维蛋白原相关蛋白或纤维蛋白原样蛋白 1）是一种新的肝分泌物，可引起肝脂肪变性并诱导胰岛素抵抗。然而，Hepassocin 在肾功能状态中的作用尚不清楚。我们的目的是研究稳定型心绞痛患者血浆 Hepassocin 水平与脂肪肝和肾功能状态的关系。 通过酶联免疫吸附试验在 395 例连续稳定型心绞痛患者中测定血浆 Hepassocin 水平。肾功能定义为估算肾小球滤过率 (eGFR)。脂肪肝通过超声和纤维化 4 (FIB-4) 指数定义。 随着 Hepassocin 三分位的增加，患者脂肪肝的患病率更高，腰围与臀围比、中性粒细胞计数、单核细胞计数和 FIB-4 指数增加，尿酸、血尿素氮水平升高，高敏 C 反应蛋白水平升高。他们的 eGFR、血清血红蛋白和白蛋白水平也逐渐降低。在多元线性逐步回归分析中，只有 eGFR 与血浆 Hepassocin 水平呈显著负相关。 我们的研究结果表明，稳定型心绞痛患者循环中的 Hepassocin 与脂肪肝和肾功能有关，这表明血浆 Hepassocin 水平升高可能与脂肪肝和 CKD 的发病机制有关。
