Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Middle Yanchang Road, Shanghai, 200072, China.
Department of Pediatrics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Middle Yanchang Road, Shanghai, 200072, China.
J Endocrinol Invest. 2022 Nov;45(11):2123-2130. doi: 10.1007/s40618-022-01844-0. Epub 2022 Jul 5.
To investigate the relationship between fibrinogen-like protein 1 (FGL-1) concentrations and various metabolic characteristics in patients with polycystic ovary syndrome (PCOS) and explore whether FGL-1 could be a predictive biomarker for PCOS.
This case-control study included 136 patients with PCOS and 34 normal controls recruited in the Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital between May 2017 and June 2021. Anthropometric characteristics, metabolic parameters, and reproductive hormones were collected. Serum FGL-1 measurement was conducted using enzyme-linked immunosorbent assay (ELISA) kits.
Serum FGL-1 concentrations were higher in patients with PCOS than in control subjects in body mass index (BMI) subgroups, insulin resistance (IR) subgroups, and hepatic function subgroups, respectively. Serum FGL-1 concentrations were significantly associated with BMI, glycosylated hemoglobin A1c (HbA1c), fasting plasma glucose (FPG), homeostasis model assessment of insulin resistance (HOMA-IR), alanine aminotransferase (ALT), aspartate aminotransferase (AST), high-density lipoprotein cholesterol (HDL-c), and serum uric acid (SUA) in all individuals. The receiver operating characteristic (ROC) curve analysis revealed that the best cutoff value for FGL-1 levels to predict PCOS was 21.02 ng/ml with a sensitivity of 74.3% and a specificity of 70.6%. Both univariate and multiple logistic regressions indicated that the odds ratio (OR) for PCOS significantly increased in the subjects with high levels of FGL-1.
In our study, FGL-1 was associated with serum aminotransferase and various metabolic indexes. Moreover, the high risk of PCOS was independently associated with the increased FGL-1 levels, which suggested that FGL-1 could be a predictive biomarker for PCOS.
研究纤维蛋白原样蛋白 1（FGL-1）浓度与多囊卵巢综合征（PCOS）患者各种代谢特征之间的关系，并探讨 FGL-1 是否可作为 PCOS 的预测生物标志物。
本病例对照研究纳入 2017 年 5 月至 2021 年 6 月期间在上海第十人民医院内分泌代谢科就诊的 136 例 PCOS 患者和 34 例正常对照。收集人体测量特征、代谢参数和生殖激素数据。采用酶联免疫吸附试验（ELISA）试剂盒检测血清 FGL-1 水平。
在 BMI 亚组、胰岛素抵抗（IR）亚组和肝功能亚组中，PCOS 患者的血清 FGL-1 浓度均高于对照组。血清 FGL-1 浓度与 BMI、糖化血红蛋白 A1c（HbA1c）、空腹血糖（FPG）、稳态模型评估的胰岛素抵抗（HOMA-IR）、丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、高密度脂蛋白胆固醇（HDL-c）和血清尿酸（SUA）在所有个体中均显著相关。受试者工作特征（ROC）曲线分析显示，FGL-1 水平预测 PCOS 的最佳截断值为 21.02 ng/ml，其敏感性为 74.3%，特异性为 70.6%。单因素和多因素逻辑回归均表明，高水平 FGL-1 患者发生 PCOS 的比值比（OR）显著增加。
在本研究中，FGL-1 与血清转氨酶和各种代谢指标相关。此外，FGL-1 水平升高与 PCOS 风险增加独立相关，提示 FGL-1 可能是 PCOS 的预测生物标志物。
