Lou Yu-Ting, Li Xiao-Long, Wang Ye, Ji Gong-Jun, Zang Yu-Feng, Wang Jue, Feng Jian-Hua
Department of Pediatrics, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou, China.
Front Psychiatry. 2020 Dec 17;11:543049. doi: 10.3389/fpsyt.2020.543049. eCollection 2020.
Tourette syndrome (TS) is a developmental neuropsychiatric disorder with onset during childhood. Because of its complex spectrum of phenotypes, the underlying pathophysiology of TS is still unclear. Resting-state functional magnetic resonance imaging demonstrated aberrant spontaneous neural synchronization in conventional frequency band (0.01-0.08 Hz) in TS. No published studies have reported abnormalities of local synchronization across different frequency bands. We estimated the alterations of local synchronization across five bands ranging from 0 to 0.25 Hz. Seventy-nine children with TS and 63 age-, sex-, and handedness-matched healthy children were recruited. Frequency-specific regional homogeneity (ReHo) and independent component analysis were used to identify functional alterations between TS and healthy children. TS patients showed significantly increased ReHo in the left precentral gyrus and decreased ReHo in the right operculum. Abnormal ReHo alterations of the superior frontal gyrus, superior parietal gyrus, anterior cingulate gyrus, putamen, superior temporal gyrus, and operculum were observed in different frequency bands. TS patients showed increased connectivity of the right superior frontal gyrus within the left executive control network. In addition, a significantly negative correlation was found between Yale Global Tic Severity Scale (YGTSS) vocal score and ReHo values of the right operculum in the highest frequency bands (0.198-0.25 Hz), while a significant positive correlation was found between YGTSS motor score and altered connectivity of the right superior frontal gyrus. The present study revealed frequency-specific abnormal alterations of ReHo in the whole brain and altered connectivity within the executive control network of TS children. Its neural importance and clinical practicability require further investigation.
抽动秽语综合征（TS）是一种在儿童期发病的发育性神经精神障碍。由于其复杂的表型谱，TS的潜在病理生理学仍不清楚。静息态功能磁共振成像显示TS患者在传统频段（0.01 - 0.08Hz）存在异常的自发神经同步。尚无已发表的研究报道不同频段局部同步的异常情况。我们估计了0至0.25Hz五个频段的局部同步变化。招募了79名患有TS的儿童和63名年龄、性别和利手匹配的健康儿童。采用频率特异性局部一致性（ReHo）和独立成分分析来识别TS患儿与健康儿童之间的功能改变。TS患者左侧中央前回的ReHo显著增加，右侧岛盖的ReHo降低。在不同频段观察到额上回、顶上回、前扣带回、壳核、颞上回和岛盖的ReHo改变异常。TS患者在左侧执行控制网络内右侧额上回的连接性增加。此外，在最高频段（0.198 - 0.25Hz），耶鲁综合抽动严重程度量表（YGTSS）的发声评分与右侧岛盖的ReHo值之间存在显著负相关，而YGTSS运动评分与右侧额上回连接性改变之间存在显著正相关。本研究揭示了TS患儿全脑ReHo的频率特异性异常改变以及执行控制网络内连接性的改变。其神经学意义和临床实用性需要进一步研究。
