Roland Antoine, Drouet Clément, Boulahdour Hatem, Cochet Alexandre, De Bari Berardino
Nuclear Medicine Department, University Hospital of Besançon, Besançon, France.
Department of Nuclear Medicine, Georges-François Leclerc Cancer Center, Dijon, France.
Quant Imaging Med Surg. 2021 Jan;11(1):172-182. doi: 10.21037/qims-19-981.
F-fluorocholine positron emission tomography/computed tomography (F-choline PET/CT) is considered a cornerstone in the staging and restaging of patients with prostate cancer (PCa). The aim of this study was to retrospectively assess unusual uptakes in patients who underwent a F-choline PET/CT for the initial staging or for the restaging of a relapsing PCa.
Three hundred and sixty-eight PCa patients were staged or restaged using F-choline PET/CT. Unusual uptakes were defined as uptakes occurring outside the usual paths of diffusion of PCa or as uptake in bone with a clear morphological evidence of nonmetastatic lesion.
We found unusual uptakes in 47/368 patients (12.8%). Among them, 41/47 presented with benign F-choline uptake, usually within lymph nodes, due to inflammatory processes (22/47). Other benign processes were found in: thyroid (3/47), adrenal gland (3/47), brain (2/47), liver (1/47), bowel (3/47), frontal sinus (1/47), lungs (4/47), parotid gland (1/47) and bone (1/47). The six remaining patients presented with a second cancer, including lymphoma (1/47), non-small cell lung cancer (4/47) and neuroendocrine tumor (1/47).
unusual uptakes on F-choline PET/CT are quite frequent and should be explored since they may correspond to non-PCa.
F-氟胆碱正电子发射断层扫描/计算机断层扫描（F-胆碱PET/CT）被认为是前列腺癌（PCa）患者分期及再分期的基石。本研究的目的是回顾性评估接受F-胆碱PET/CT进行初始分期或复发性PCa再分期患者的异常摄取情况。
368例PCa患者接受了F-胆碱PET/CT分期或再分期。异常摄取被定义为发生在PCa通常扩散途径之外的摄取，或在骨中出现且有明确非转移性病变形态学证据的摄取。
我们在47/368例患者（12.8%）中发现了异常摄取。其中，41/47例表现为良性F-胆碱摄取，通常在淋巴结内，原因是炎症过程（22/47）。还发现其他良性过程存在于：甲状腺（3/47）、肾上腺（3/47）、脑（2/47）、肝脏（1/47）、肠道（3/47）、额窦（1/47）、肺（4/47）、腮腺（1/47）和骨（1/47）。其余6例患者患有第二种癌症，包括淋巴瘤（1/47）、非小细胞肺癌（4/47）和神经内分泌肿瘤（1/47）。
F-胆碱PET/CT上的异常摄取相当常见，应进行探究，因为它们可能与非PCa相关。
