Wang Hezhu, Yang Xiaoqing, Chen Xiaojing, Xie Huihui, Wang Junxia, Zhang Yuquan
Department of Obstetrics and Gynecology, Affiliated Hospital of Nantong University, Jiangsu, China.
Jiangsu Taizhou Peoples' Hospital, Jiangsu, China.
J Obstet Gynaecol Res. 2021 Jan;47(1):320-328. doi: 10.1111/jog.14526. Epub 2021 Jan 3.
Maternal complications caused by the cesarean delivery inhibit the capability of preserving the uterus and subsequent fertility. However, successful restoration of the incisional scar continuously still remains a challenge. This work was to evaluate the repairing effect of Human Wharton's Jelly Mesenchymal Stem Cells (hWJ-MSC) on incisional scar of the uterine.
Eighteen rats were randomly assigned into two groups and nine for each: one group injected with hWJ-MSC in phosphate buffer saline (PBS) and the other injected with PBS for comparison.
With hWJ-MSC in PBS injected, the uterine endometrium and myometrium with full-thickness injury were restored and the functionality was greatly improved in comparison with the group only with PBS injected.
The hWJ-MSC can repair the injured uterine effectively by promoting the uterine endometrium and myometrium cells proliferation and according to the chi-square analysis the pregnancy is improved.
剖宫产引起的产妇并发症会抑制保留子宫及后续生育能力。然而，切口瘢痕的持续成功修复仍然是一项挑战。本研究旨在评估人脐带华通氏胶间充质干细胞（hWJ-MSC）对子宫切口瘢痕的修复效果。
将18只大鼠随机分为两组，每组9只：一组注射磷酸盐缓冲盐水（PBS）中的hWJ-MSC，另一组注射PBS作为对照。
与仅注射PBS的组相比，注射PBS中的hWJ-MSC后，全层损伤的子宫内膜和肌层得以修复，功能得到显著改善。
hWJ-MSC可通过促进子宫内膜和肌层细胞增殖有效修复受损子宫，根据卡方分析，妊娠情况得到改善。
