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65岁以上人群是否应进行常规流感免疫接种?持肯定观点。

Is routine influenza immunization indicated for people over 65 years of age? An affirmative view.

作者信息

Thompson M P

机构信息

Department of Family Medicine, Medical College of Georgia, Augusta 30912.

出版信息

J Fam Pract. 1988 Feb;26(2):211-4.

PMID:3339325
Abstract

Influenza is usually a minor, self-limiting illness, but for the elderly, especially the elderly who have chronic illnesses, it may be a severe or fatal disease. During influenza epidemics this disease may not always be recognized clinically as influenza but may appear as an acute decompensation in a patient with a known chronic illness. The influenza vaccine is not perfect, but it has been shown to be effective in the elderly. Reactions to the vaccine are usually minor and administration costs are low. Experience with influenza vaccine since the early 1940s has led to an improved, more pure vaccine formulation, has developed worldwide systems of tracking the dominant circulating viral strains, and has refined recommendations for vaccine usage based on clinical studies of its efficacy and cost effectiveness. Physicians should be aware of the present limitations of the existing studies and the imperfections of the vaccines, but in the elderly population, a proven intervention that will offer a substantial degree of protection during the influenza season should not be withheld. Most of the existing evidence suggests that the vaccine is effective and that physicians should be more stringent in their influenza immunization practices with the elderly. The elderly who are at high risk should be of high priority for receiving influenza vaccine, and the vaccine should also be recommended to healthy individuals aged 65 years and older because of its proven efficacy for reducing attack rates when appropriate viral strains are used.

摘要

流感通常是一种轻微的自限性疾病,但对于老年人,尤其是患有慢性疾病的老年人来说,它可能是一种严重的甚至致命的疾病。在流感流行期间,这种疾病在临床上可能并不总是被识别为流感,而是可能表现为已知慢性病患者的急性失代偿。流感疫苗并不完美,但已证明对老年人有效。对疫苗的反应通常较小,接种成本也较低。自20世纪40年代初以来,流感疫苗的使用经验带来了改进的、更纯的疫苗配方,建立了全球范围内追踪主要流行病毒株的系统,并根据其疗效和成本效益的临床研究完善了疫苗使用建议。医生应该意识到现有研究的当前局限性以及疫苗的不完美之处,但在老年人群中,不应拒绝使用这种已被证明在流感季节能提供相当程度保护的干预措施。现有大部分证据表明疫苗是有效的,医生在对老年人进行流感免疫接种时应更加严格。高危老年人应优先接种流感疫苗,对于65岁及以上的健康个体也应推荐接种,因为当使用合适的病毒株时,疫苗在降低发病率方面已被证明有效。

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