Department of Pathology, University of Medicine, Targu Mures, Romania.
J Clin Pathol. 2009 Oct;62(10):942-4. doi: 10.1136/jcp.2008.063727.
Müllerian adenosarcomas are tumours of low malignant potential with proliferation of benign glands and low grade endometrial stromal sarcoma (LGESS). Unusually, the latter may include foci of uterine tumours resembling ovarian sex-cord tumours (UTROSCT). Two cases of uterine adenosarcomas massively overgrown by UTROSCT are reported, for the first time. The patients, aged 71 and 64, one receiving tamoxifen, presented with intracavitary polypoid adenosarcomas; each was overgrown by an immunopathologically characteristic UTROSCT that constituted more than 75% of its volume. Periglandular CD10+LGESS represented less than 25%. Both are alive and well after 5 and 3 years, respectively. Compared to the poor prognosis of adenosarcomas overgrown by high grade sarcomata, the cases reported here had a benign behaviour. Quantitative assessment of volume percentage of the potentially aggressive LGESS, CD10+ areas should be considered as a relevant prognostic histological parameter in these tumours.
苗勒管混合性腺肉瘤是一种低度恶性潜能的肿瘤，由良性腺体和低度子宫内膜间质肉瘤（LGESS）组成。不常见的是，后者可能包含类似于卵巢性索肿瘤（UTROSCT）的子宫肿瘤灶。报告了两例由 UTROSCT 大量过度生长的子宫腺肉瘤，这是首次报道。这两名患者分别为 71 岁和 64 岁，一名接受了他莫昔芬治疗，表现为腔内息肉状腺肉瘤；每个肿瘤都被具有免疫病理学特征的 UTROSCT 过度生长，其体积超过 75%。周围腺体的 CD10+LGESS 占不到 25%。两名患者分别在 5 年和 3 年后仍然存活且状况良好。与由高级肉瘤过度生长的腺肉瘤预后不良相比，这里报告的病例表现出良性行为。在这些肿瘤中，定量评估潜在侵袭性 LGESS、CD10+区域的体积百分比应被视为相关的预后组织学参数。
