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尼达尼布——特发性肺纤维化患者治疗的疗效、安全性及实际情况

Nintedanib - efficacy, safety and practical aspects of treatment for patients with idiopathic pulmonary fibrosis.

作者信息

Martusewicz-Boros Magdalena, Górska Katarzyna

机构信息

3rd Lung Diseases and Oncology Department, National Tuberculosis and Lung Diseases Research Institute in Warsaw, Warsaw, Poland.

Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Warsaw, Poland.

出版信息

Adv Respir Med. 2020;88(6):599-607. doi: 10.5603/ARM.a2020.0190.

Abstract

Idiopathic pulmonary fibrosis (IPF) is a rare disease with progressive course and a very unfavourable prognosis. Antifibrotic drugs are a chance to reduce the rate of disease progression and extend the life of IPF patients. One of these drugs is nintedanib, an oral tyrosine kinase inhibitor. In the following article, the reader will find a summary of current knowledge on the efficacy and safety of nintedanib treatment of IPF patients. This study uses data from pivotal studies and experience from everyday clinical practice indicating a wide range of possible applications of the drug in IPF patients.

摘要

特发性肺纤维化(IPF)是一种病程呈进行性且预后极差的罕见疾病。抗纤维化药物是降低疾病进展速度并延长IPF患者寿命的一个契机。其中一种药物是尼达尼布,一种口服酪氨酸激酶抑制剂。在接下来的文章中,读者将找到关于尼达尼布治疗IPF患者的疗效和安全性的当前知识总结。本研究使用了关键研究的数据以及日常临床实践经验,表明该药物在IPF患者中有广泛的可能应用。

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