Eye Hospital and School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, Zhejiang, China.
State Key Laboratory of Optometry, Ophthalmology and Vision Science, Wenzhou, Zhejiang, China.
Invest Ophthalmol Vis Sci. 2021 Jan 4;62(1):8. doi: 10.1167/iovs.62.1.8.
To explore the association of choroidal vascularity and choriocapillaris blood perfusion with myopic severity in anisomyopes.
Refractive error, axial length (AL), and other biometric parameters were measured in 34 anisomyopic young adults. Macular choroidal thickness (ChT) and choroidal vascularity, including total choroidal area (TCA), luminal area (LA), stromal area (SA), and choroidal vascularity index (CVI), were determined from swept-source optical coherence tomography (SS-OCT) vertical and horizontal B-scans. The percentage of choriocapillaris flow voids (FV%) was obtained from en face SS-OCT-angiography.
The spherical equivalent refraction (SER) was -3.35 ± 1.25 diopters in the more myopic eyes and -1.25 ± 1.17 diopters in the less myopic eyes (P < 0.001). The interocular difference in SER was highly correlated with that in AL (P < 0.001). The macular ChT, TCA, LA, and SA were smaller in the more myopic eyes than in the less myopic eyes in both vertical and horizontal scans (all P < 0.001). Importantly, the CVIs in vertical and horizontal scans were smaller and the FV% was greater in the more myopic eyes (P < 0.05). In vertical scans, the interocular difference in CVIs was correlated with that in the SER, AL, and ChT (all P < 0.05). The interocular difference in FV% was correlated with that in SER, AL, and vertical and horizontal ChTs (all P < 0.05).
Choroidal vascularity and choriocapillaris blood perfusion were lower in the more myopic eyes of anisomyopic adults. These changes were correlated with the severity of myopia and choroidal thinning, indicating that choroidal blood flow is disturbed in human myopia.
探讨双眼屈光参差患者脉络膜血管密度和脉络膜毛细血管血灌注与近视程度的关系。
对 34 名双眼屈光参差的年轻成年人进行屈光不正、眼轴（AL）和其他生物测量参数的测量。从扫频源光学相干断层扫描（SS-OCT）垂直和水平 B 扫描中确定黄斑脉络膜厚度（ChT）和脉络膜血管密度，包括总脉络膜面积（TCA）、管腔面积（LA）、基质面积（SA）和脉络膜血管密度指数（CVI）。从 SS-OCT 血管造影的正面图像中获得脉络膜毛细血管血流缺失（FV%）的百分比。
在更近视的眼中，等效球镜（SER）为-3.35 ± 1.25 屈光度，在较不近视的眼中为-1.25 ± 1.17 屈光度（P < 0.001）。SER 的眼间差异与 AL 的眼间差异高度相关（P < 0.001）。在垂直和水平扫描中，更近视的眼中黄斑 ChT、TCA、LA 和 SA 均小于较不近视的眼中（均 P < 0.001）。重要的是，垂直和水平扫描中的 CVI 更小，更近视的眼中 FV%更大（P < 0.05）。在垂直扫描中，CVI 的眼间差异与 SER、AL 和 ChT 相关（均 P < 0.05）。FV%的眼间差异与 SER、AL 和垂直及水平 ChT 相关（均 P < 0.05）。
双眼屈光参差成年人中更近视眼的脉络膜血管密度和脉络膜毛细血管血流灌注较低。这些变化与近视的严重程度和脉络膜变薄相关，表明人眼近视时脉络膜血流受到干扰。
