Sun Gongpeng, Emu Muga, Lin Rong, Gong Jing, Zhao Ling, Lei Chunyan, Yang Bi, Ma Ke, Zhang Meixia
Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China.
Research Laboratory of Macular Disease, West China Hospital, Sichuan University, Chengdu, China.
Invest Ophthalmol Vis Sci. 2025 Jul 1;66(9):31. doi: 10.1167/iovs.66.9.31.
To investigate regional differences in Gaussian retinal curvature (RC) between fellow eyes of anisometropic patients and their associations with interocular disparities in myopic parameters.
In this cross-sectional study, ultra-widefield swept-source optical coherence tomography (24 mm × 20 mm field) was performed in 121 anisometropic patients. Three-dimensional retinal morphology reconstruction based on Bruch's membrane was used to derive Gaussian RC. The retina was segmented into macular, peripheral, and six concentric annular regions (I-VI). Paired t-tests or Wilcoxon signed-rank tests were applied to evaluate interocular RC differences, with Spearman correlation analysis examining associations between RC variations and myopic parameter disparities.
Mean interocular differences were 1.95 ± 0.95 D for spherical equivalent (SE) and 0.79 ± 0.46 mm for axial length (AL). The more myopic eye exhibited significantly steeper macular RC (P < 0.001) and flatter peripheral RC (P < 0.001) compared to the fellow eye. Macular/peripheral RC disparities demonstrated significant correlations with SE/AL differences (both P < 0.05). Region-specific analysis revealed positive correlations between AL and RC I-III differentials, whereas inverse correlations were observed for RC V-VI (all P < 0.01).
Anisometropic patients demonstrate biomechanical divergence characterized by macular steepening and peripheral flattening in the more myopic eye during axial elongation, suggesting region-dependent retinal adaptation mechanisms.
研究屈光参差患者双眼高斯视网膜曲率（RC）的区域差异及其与近视参数眼间差异的关联。
在这项横断面研究中，对121例屈光参差患者进行了超广角扫频光学相干断层扫描（24 mm×20 mm视场）。基于布鲁赫膜的三维视网膜形态重建用于推导高斯RC。视网膜被分割为黄斑区、周边区和六个同心环形区域（I - VI）。采用配对t检验或威尔科克森符号秩检验评估眼间RC差异，采用斯皮尔曼相关分析检验RC变化与近视参数差异之间的关联。
球镜等效度（SE）的平均眼间差异为1.95±0.95 D，眼轴长度（AL）的平均眼间差异为0.79±0.46 mm。与对侧眼相比，近视程度更高的眼睛黄斑RC明显更陡峭（P < 0.001），周边RC更平坦（P < 0.001）。黄斑/周边RC差异与SE/AL差异显著相关（均P < 0.05）。区域特异性分析显示AL与RC I - III差异之间呈正相关，而RC V - VI则呈负相关（均P < 0.01）。
屈光参差患者表现出生物力学差异，其特征为在眼轴伸长过程中近视程度更高的眼睛黄斑变陡、周边变平，提示视网膜存在区域依赖性适应机制。
