Postgraduate Program in Pneumological Sciences, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
Bone Marrow Transplant Unit, HCPA, Porto Alegre, Brazil.
Support Care Cancer. 2021 Jul;29(7):4015-4021. doi: 10.1007/s00520-020-05947-3. Epub 2021 Jan 4.
Hematopoietic stem cell transplantation (HSCT) is used as a treatment for several diseases. The objective was to evaluate the functional capacity, pulmonary function, and quality of life (QoL) in HSCT survivors.
The patients were submitted to spirometry and six-minute walk test (6MWT) and evaluation of QoL (Functional Assessment of Cancer Therapy Bone Marrow Transplantation-FACT-BMT) and the level of physical activity (Human Activity Profile-HAP) in the post-HSCT outpatient ambulatory.
The sample was composed of 103 individuals with a mean age of 42.1 ± 12 and a median HSCT time of 5 (2-11) years. The average distance walked in the 6MWT was 524.7 ± 73.5 m; the FACT-BMT score, 82 ± 8.7 points; FEV, 76.8 ± 22.6%; and HAP, 71.9 ± 11.2 points. There was a significant difference between debilitated and physically active individuals for the variables: forced expiratory volume in the first second (FEV) in liters (p = 0.008) and % of predicted (p = 0.017), FEV/FVC (p = 0.032), distance on the 6MWT (p < 0.001), fatigue after the 6MWT (p < 0.001), and physical well-being (p = 0.005).
HSCT survivors have long-term changes in functional capacity, pulmonary function, and QoL. Subjects more active had better results in pulmonary function and functional capacity.
造血干细胞移植（HSCT）被用于治疗多种疾病。本研究旨在评估 HSCT 幸存者的功能能力、肺功能和生活质量（QoL）。
患者接受了肺量测定法和 6 分钟步行试验（6MWT），以及 QoL 评估（癌症治疗功能评估-骨髓移植问卷-FACT-BMT）和体力活动水平（人类活动概况-HAP）的评估。
样本由 103 名年龄 42.1 ± 12 岁、中位 HSCT 时间为 5（2-11）年的个体组成。6MWT 的平均步行距离为 524.7 ± 73.5m；FACT-BMT 评分为 82 ± 8.7 分；FEV 为 76.8 ± 22.6%；HAP 为 71.9 ± 11.2 分。在衰弱和活跃个体之间，以下变量存在显著差异：第一秒用力呼气量（FEV）（p = 0.008）和预测值的百分比（p = 0.017）、FEV/FVC（p = 0.032）、6MWT 距离（p < 0.001）、6MWT 后疲劳（p < 0.001）和身体幸福感（p = 0.005）。
HSCT 幸存者的功能能力、肺功能和 QoL 存在长期变化。更活跃的患者在肺功能和功能能力方面有更好的结果。
