Homer L D, Small A
Am J Physiol. 1977 Sep;233(3):H350-5. doi: 10.1152/ajpheart.1977.233.3.H350.
A model incorporating the effects of recirculation time lag, cardiac output, clearance, volume of distribution, and the variance of the distribution of recirculation times is applied to the analysis of indicator dilution curves. Experiments on dogs with use of radioactively labeled diethylenetriaminepentaacetic acid were done to evaluate the model. This five-parameter model can be fitted to data obtained during the period from less than 1 min to 3 h after a single injection of indicator. Estimates of cardiac output and clearance are in satisfactory agreement with estimates obtained by alternative techniques. Estimates of the time lag and volume of distribution are of physiologically plausible magnitude. The variance of the distribution of recirculation times is a new parameter, of which the possible usefulness to physiologists is discussed.
一个包含再循环时间滞后、心输出量、清除率、分布容积以及再循环时间分布方差影响的模型被应用于指示剂稀释曲线的分析。使用放射性标记的二乙三胺五乙酸对狗进行实验以评估该模型。这个五参数模型可以拟合单次注射指示剂后不到1分钟至3小时期间获得的数据。心输出量和清除率的估计值与通过其他技术获得的估计值吻合良好。时间滞后和分布容积的估计值在生理上具有合理的量级。再循环时间分布的方差是一个新参数，文中讨论了其对生理学家可能具有的用途。
