Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Department of Neurology and Clinical Neurophysiology, St Olav University Hospital, Trondheim, Norway.
FEBS J. 2021 Dec;288(24):7243-7255. doi: 10.1111/febs.15694. Epub 2021 Jan 17.
Animal models contribute greatly to our understanding of brain development and function as well as its dysfunction in neurological diseases. Epilepsy research is a very good example of how animal models can provide us with a mechanistic understanding of the genes, molecules, and pathophysiological processes involved in disease. Over the course of the last two decades, zebrafish came in as a new player in epilepsy research, with an expanding number of laboratories using this animal to understand epilepsy and to discover new strategies for preventing seizures. Yet, zebrafish as a model offers a lot more for epilepsy research. In this viewpoint, we aim to highlight some key contributions of zebrafish to epilepsy research, and we want to emphasize the great untapped potential of this animal model for expanding these contributions. We hope that our suggestions will trigger further discussions between clinicians and researchers with a common goal to understand and cure epilepsy.
动物模型极大地促进了我们对大脑发育和功能以及神经疾病中功能障碍的理解。癫痫研究就是一个很好的例子，说明动物模型如何为我们提供疾病涉及的基因、分子和病理生理过程的机制理解。在过去的二十年中，斑马鱼作为癫痫研究的新成员加入，越来越多的实验室使用这种动物来了解癫痫，并发现预防癫痫发作的新策略。然而，斑马鱼作为一种模型为癫痫研究提供了更多的可能性。在本观点中，我们旨在强调斑马鱼对癫痫研究的一些关键贡献，并强调这种动物模型在扩大这些贡献方面的巨大未开发潜力。我们希望我们的建议将引发有共同目标的临床医生和研究人员之间的进一步讨论，即理解和治疗癫痫。
