Departments of Rehabilitation Medicine and.
Department of Otorhinolaryngology, Qingdao Women's and Children's Hospital, Qingdao, China.
Neurologist. 2020 Dec 30;26(1):6-9. doi: 10.1097/NRL.0000000000000303.
To observe the effect of low-frequency repetitive transcranial magnetic stimulation (rTMS) on patients with nonfluent aphasia after stroke.
Thirty patients were divided into control, rTMS, and 2 times a day low-frequency rTMS (2rTMS) groups, and all 3 groups had intensive speech therapy (ST). Patients were assessed by western aphasia battery (WAB) scale. The spontaneous language, listening comprehension, retelling, and naming were scored, respectively. The expression of brain-derived neurotrophic factor (BDNF) in peripheral blood was detected by enzyme-linked immunosorbent assay.
There was significant difference in aphasia quotient after treatment in the 3 groups. The values of the 4 dimensions in the WAB score of the rTMS group were higher than those in the control group. The WAB scores in the 2rTMS group were higher than those in the rTMS group. After 2 weeks treatment, the BDNF levels in the rTMS group and the 2rTMS group were significantly higher than those in the control group. Four weeks later, the 2rTMS group was significantly increased compared with the control group and the rTMS group.
Low-frequency rTMS combined with conventional ST treatment can effectively improve the language function of patients with nonfluent aphasia after stroke. Two times a day low-frequency rTMS therapy combined with conventional ST treatment can improve the language function of patients with nonfluent aphasia after stroke more effectively and it also promote the expression of BDNF more effectively, thereby improving nerve repair and protecting brain tissue.
观察低频重复经颅磁刺激（rTMS）对脑卒中后非流利性失语症患者的疗效。
将 30 例患者分为对照组、rTMS 组和 2 次/d 低频 rTMS（2rTMS）组，3 组均进行强化语言治疗（ST）。采用西方失语成套测验（WAB）量表评估患者，分别对自发性语言、听理解、复述和命名进行评分，采用酶联免疫吸附试验检测外周血脑源性神经营养因子（BDNF）的表达。
治疗后 3 组患者失语商均有显著差异，rTMS 组 WAB 评分的 4 个维度评分均高于对照组，2rTMS 组 WAB 评分均高于 rTMS 组。治疗 2 周后，rTMS 组和 2rTMS 组 BDNF 水平明显高于对照组，治疗 4 周后，2rTMS 组明显高于对照组和 rTMS 组。
低频 rTMS 联合常规 ST 治疗可有效改善脑卒中后非流利性失语症患者的语言功能，2 次/d 低频 rTMS 治疗联合常规 ST 治疗可更有效地改善脑卒中后非流利性失语症患者的语言功能，更有效地促进 BDNF 的表达，从而促进神经修复，保护脑组织。
