Centre for Neurogenic Communication Disorders Research, School of Health and Rehabilitation Sciences, University of Queensland, Australia.
Centre for Neurogenic Communication Disorders Research, School of Health and Rehabilitation Sciences, University of Queensland, Australia.
Brain Stimul. 2012 Jul;5(3):274-286. doi: 10.1016/j.brs.2011.03.005. Epub 2011 Apr 13.
Repetitive transcranial magnetic stimulation (rTMS) has been identified as a potentially valuable tool for the rehabilitation of language impairment after left hemisphere (LH) stroke, in populations of persons with chronic aphasia. Applied to a homologue to Broca's area, rTMS is posited to modulate bilateral language networks, promoting measurable behavioral language change, in accordance with theories of transcallosal disinhibition arising from the damaged LH.
OBJECTIVE/HYPOTHESIS: The current investigation is an open-label study, presenting detailed case and group presentations on a population of seven nonfluent aphasic participants. Behavioral language performance is presented on expressive and receptive language measures up to 8 months after a 10-day protocol of 1 Hz stimulation. This research aims to provide longitudinal behavioral language outcomes for persons with aphasia, subsequent to rTMS and supplement previous studies to inform the clinical efficacy of rTMS.
In accordance with previous investigations, significant improvements in picture naming, spontaneous elicited speech and auditory comprehension were found. Time of testing was identified as a significant main effect. Significant improvements in picture naming accuracy and decreases in picture naming latency were also identified. The results demonstrate sustained language improvements up to 8 months subsequent to TMS application.
The results of this investigation are consistent with the findings of previous research studies, reporting behavioral language changes after rTMS in nonfluent aphasia. Additional evidence is provided to demonstrate that rTMS may facilitate retrieval mechanisms involved in picture naming.
重复经颅磁刺激（rTMS）已被确定为一种有潜力的工具，可用于治疗左半球（LH）卒中后慢性失语症患者的语言障碍康复。应用于Broca 区同源区，rTMS 被认为可以调节双侧语言网络，根据受损 LH 引起的胼胝体抑制的跨皮质理论，促进可测量的行为语言变化。
目的/假设：本研究为开放性研究，对 7 名非流畅性失语症患者进行了详细的病例和组内介绍。在 10 天 1Hz 刺激方案结束后长达 8 个月的时间内，通过表达性和接受性语言测量来呈现行为语言表现。本研究旨在为 rTMS 后失语症患者提供纵向行为语言结果，并补充先前的研究结果，以告知 rTMS 的临床疗效。
与先前的研究一致，发现图片命名、自发引出的言语和听觉理解能力显著提高。测试时间被确定为一个显著的主效应。图片命名准确性的显著提高和命名潜伏期的显著降低也被发现。结果表明，在 TMS 应用后长达 8 个月的时间内，语言持续改善。
本研究结果与先前研究报告的 rTMS 后非流畅性失语症的行为语言变化研究结果一致。进一步的证据表明，rTMS 可能有助于涉及图片命名的检索机制。
