West Coast Retina Medical Group, San Francisco, California.
The Department of Ophthalmology, California Pacific Medical Center, San Francisco, California, USA. Dr. Alsberge is now with The Department of Ophthalmology, Northwest Permanente, Portland, Oregon.
Retin Cases Brief Rep. 2023 Jan 1;17(1):18-22. doi: 10.1097/ICB.0000000000001113. Epub 2020 Dec 21.
To report a case of Vogt-Koyanagi-Harada-like uveitis followed by melanoma-associated retinopathy with focal chorioretinal atrophy and subsequent choroidal neovascularization in a patient with metastatic cutaneous melanoma.
Case report. Main outcome measures include external photography, anterior segment photography, ophthalmoscopic examination, fundus photography, fluorescein angiography, indocyanine green angiography, spectral domain optical coherence tomography, optical coherence tomography angiography, and electroretinography.
A 68-year-old man with a history cutaneous melanoma presented with Vogt-Koyanagi-Harada-like uveitis. Work-up revealed a pelvic mass, which was excised and found to be metastatic melanoma. Two years later, the patient developed melanoma-associated retinopathy with focal chorioretinal atrophy and adjacent choroidal neovascularization.
Patients with metastatic cutaneous melanoma can develop distinct and sequential paraneoplastic ocular complications. Onset of a Vogt-Koyanagi-Harada-like uveitis may be a good prognostic factor for survival in patients with metastatic cutaneous melanoma.
报告 1 例转移性皮肤黑色素瘤患者出现 Vogt-小柳-原田（Vogt-Koyanagi-Harada，VKH）样葡萄膜炎，继之发生伴局灶性脉络膜视网膜萎缩的黑色素瘤相关视网膜病变，随后出现脉络膜新生血管。
病例报告。主要观察指标包括外眼照相、眼前节照相、眼底检查、眼底照相、荧光素血管造影、吲哚青绿血管造影、频域光学相干断层扫描、光相干断层扫描血管造影和视网膜电图。
1 例 68 岁男性，有皮肤黑色素瘤病史，出现 VKH 样葡萄膜炎。检查发现盆腔有一肿块，切除后证实为转移性黑色素瘤。2 年后，患者发生伴局灶性脉络膜视网膜萎缩和邻近脉络膜新生血管的黑色素瘤相关视网膜病变。
转移性皮肤黑色素瘤患者可出现独特的、相继发生的副肿瘤性眼部并发症。出现 VKH 样葡萄膜炎可能是转移性皮肤黑色素瘤患者生存的良好预后因素。
