Department of Psychiatry, National Center for Children Healthy, Beijing Children's Hospital, Capital Medical University, Beijing, China.
J Child Adolesc Psychopharmacol. 2021 Mar;31(2):95-101. doi: 10.1089/cap.2020.0051. Epub 2021 Jan 4.
The outcome of pediatric obsessive-compulsive disorder (OCD) is still unclear. In the present study, long-term rates and predictors of remission were used to identify potential factors influencing the outcome of pediatric OCD. Using meta-analysis techniques, we calculated the pooled rate of remission and performed subgroup analyses to identify potential heterogeneities, and the meta-regression analysis was used as a predictor. A total of 18 studies including 1389 participants were identified, and the follow-up periods ranged from 1 to 16 years. The pooled remission rate of pediatric OCD was 62% (95% confidence interval: 52-72). Shorter duration of OCD at baseline ( = 78.04%, < 0.0001) predicted higher rates of remission. The outcome of pediatric OCD seems to be better than the past. Shorter duration of illness appears to be related to a better outcome. Early detection of pediatric OCD and early intervention play an important role in good prognosis. In the future, studies based on multicenter, longer follow-up studies with larger samples were needed to confirm these issues for the outcome of pediatric OCD.
儿童强迫症（OCD）的结局仍不清楚。本研究采用长期缓解率和预测因素来确定影响儿童 OCD 结局的潜在因素。我们使用荟萃分析技术计算了缓解的总率，并进行了亚组分析以确定潜在的异质性，以及使用元回归分析作为预测因素。共纳入了 18 项研究，包括 1389 名参与者，随访时间为 1 至 16 年。儿童 OCD 的总体缓解率为 62%（95%置信区间：52-72）。基线时 OCD 持续时间较短（ = 78.04%， < 0.0001）预示着更高的缓解率。儿童 OCD 的结局似乎比过去要好。疾病持续时间较短与更好的结局有关。早期发现儿童 OCD 并早期干预对良好预后起着重要作用。未来需要基于多中心、更长随访时间和更大样本量的研究来证实这些问题对儿童 OCD 结局的影响。
