Al-Mufti W, Bomsel-Helmreich O, Christidès J P
Unité 187, INSERM, Clamart, France.
J Reprod Fertil. 1988 Jan;82(1):15-25. doi: 10.1530/jrf.0.0820015.
Healthy follicles with 2-24 oocytes were observed in adult rabbit ovaries during all phases of folliculogenesis from primary to preovulatory follicles. Most follicles contained 2-3 oocytes which developed according to their topographical situation in the follicle. The central oocyte in a normal topographical situation has an almost normal growth and development up to metaphase II and cumulus expansion. The peripheral oocytes grow more slowly: most do not attain the normal size or resume meiosis and remain surrounded by ordinary granulosa cells. When the number of oocytes is higher than 3, the peripheral oocytes develop even more slowly, as do the central ones. It demonstrates the necessity for the oocyte to occupy a certain position inside the follicle and to reach a size which allows resumption of meiosis; the cumulus responds only to oocytes of normal size and position. We suggest that, despite the relative frequency of binovular follicles, fertilization of two oocytes originating from one follicle is unlikely.
在成年兔卵巢中，从初级卵泡到排卵前卵泡的卵泡发生各阶段，均观察到含有2 - 24个卵母细胞的健康卵泡。大多数卵泡含有2 - 3个卵母细胞，这些卵母细胞根据其在卵泡中的位置发育。处于正常位置的中央卵母细胞直至减数分裂中期II和卵丘扩张，其生长和发育几乎正常。周边卵母细胞生长较慢：大多数未达到正常大小或恢复减数分裂，仍被普通颗粒细胞包围。当卵母细胞数量超过3个时，周边卵母细胞和中央卵母细胞发育得更慢。这表明卵母细胞必须在卵泡内占据一定位置并达到允许恢复减数分裂的大小；卵丘仅对正常大小和位置的卵母细胞作出反应。我们认为，尽管双卵卵泡相对常见，但源自一个卵泡的两个卵母细胞受精的可能性不大。
