Department of Reproductive Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China.
J Assist Reprod Genet. 2022 Jun;39(6):1351-1357. doi: 10.1007/s10815-022-02465-5. Epub 2022 Mar 23.
The significance of conjoined oocytes in the clinical in vitro fertilization (IVF) laboratory setting has been questionable due to the extremely limited data available. This issue is discussed by presenting one case for conjoined oocyte observed in the program of the assisted reproduction and by including a review of corresponding literature. This report describes a successful clinical pregnancy with subsequent live birth from a conjoined oocyte. To our knowledge, there are only three reported cases of successful live birth from conjoined oocytes, but this is the first case of live birth from a blastocyst derived from a conjoined oocyte fertilized using intracytoplasmic sperm injection (ICSI) in a frozen embryo transfer cycle. Moreover, this study reports the first time that live birth of a conjoined oocyte is achieved without removing the degenerated immature oocyte prior to transfer. It demonstrates that the degenerated immature oocyte has no adverse effect on subsequent embryo development and pregnancy outcome. In addition, we reviewed the literature to evaluate the origin, incidence, safety, and significance of conjoined oocytes in reproductive health. We further confirm previous reports that demonstrate that a mature oocyte from conjoined-oocyte complexes can be fertilized by standard IVF or ICSI and lead to the development of a blastocyst, subsequent pregnancy, and live birth.
由于可用数据极其有限，在临床体外受精（IVF）实验室环境中，联体卵母细胞的意义一直存在争议。本文通过介绍一例辅助生殖项目中观察到的联体卵母细胞，并结合相关文献复习对此问题进行了讨论。本报告描述了一例成功的临床妊娠并随后从联体卵母细胞中获得活产。据我们所知，仅有三例成功的联体卵母细胞活产的报道，但这是首例通过胞浆内单精子注射（ICSI）受精来自联体卵母细胞的胚胎在冷冻胚胎移植周期中获得的活产。此外，本研究首次报告了在不转移前去除退化的未成熟卵母细胞的情况下实现联体卵母细胞活产。这表明退化的未成熟卵母细胞对随后的胚胎发育和妊娠结局没有不良影响。此外，我们回顾了文献，评估了联体卵母细胞在生殖健康中的起源、发生率、安全性和意义。我们进一步证实了之前的报告，即来自联体卵母细胞复合物的成熟卵母细胞可以通过标准的 IVF 或 ICSI 受精，并导致囊胚发育、随后妊娠和活产。
