Australian Centre for Precision Health, University of South Australia Cancer Research Institute, University of South Australia, Adelaide, SA 5000, Australia.
Department of Pharmacology and Clinical Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa 1000, Ethiopia.
Nutrients. 2020 Dec 30;13(1):109. doi: 10.3390/nu13010109.
The relationship between depression and vitamin D deficiency is complex, with evidence mostly from studies affected by confounding and reverse causality. We examined the causality and direction of the relationship between 25-hydroxyvitamin D (25(OH)D) and depression in bi-directional Mendelian randomization (MR) analyses using information from up to 307,618 white British participants from the UK Biobank and summary results from the SUNLIGHT ( = 79,366) and Psychiatric Genomics consortia (PGC 113,154 cases and 218,523 controls). In observational analysis, the odds of depression decreased with higher 25(OH)D concentrations (adjusted odds ratio (OR) per 50% increase 0.95, 95%CI 0.94-0.96). In MR inverse variance weighted (IVW) using the UK Biobank, there was no association between genetically determined serum 25(OH)D and depression (OR per 50% higher 0.97, 95%CI 0.90-1.05) with consistent null association across all MR approaches and in data from PGC consortium. In contrast, genetic liability to depression was associated with lower 25(OH)D concentrations (MR IVW -3.26%, -4.94%--1.55%), with the estimates remaining generally consistent after meta-analysing with the consortia. In conclusion, we found genetic evidence for a causal effect of depression on lower 25(OH)D concentrations, however we could not confirm a beneficial effect of nutritional vitamin D status on depression risk.
抑郁症与维生素 D 缺乏之间的关系很复杂，大多数证据来自于易受混杂因素和反向因果关系影响的研究。我们利用英国生物库中多达 307618 名白种英国人的信息以及来自 SUNLIGHT（=79366）和 Psychiatric Genomics 联盟（PGC113154 例病例和 218523 例对照）的汇总结果，通过双向 Mendelian 随机化（MR）分析来检验 25-羟维生素 D（25（OH）D）与抑郁症之间的因果关系和方向。在观察性分析中，随着 25（OH）D 浓度的升高，患抑郁症的几率降低（每增加 50%的调整后比值比为 0.95，95%置信区间为 0.94-0.96）。在使用英国生物库的 MR 反方差加权（IVW）中，遗传决定的血清 25（OH）D 与抑郁症之间没有关联（每增加 50%的比值比为 0.97，95%置信区间为 0.90-1.05），所有 MR 方法和 PGC 联盟的数据均显示出一致的零关联。相比之下，抑郁的遗传易感性与较低的 25（OH）D 浓度相关（MR IVW -3.26%，-4.94%-1.55%），在与联盟进行荟萃分析后，这些估计值基本保持一致。总之，我们发现了遗传证据表明抑郁症对较低的 25（OH）D 浓度有因果作用，但我们不能证实营养维生素 D 状态对抑郁症风险有有益影响。
