deVere White R W, Deitch A D, West B, Fitzpatrick J M
Department of Urology, University of California, Davis School of Medicine.
J Urol. 1988 Feb;139(2):279-82. doi: 10.1016/s0022-5347(17)42386-x.
Two blind retrospective flow cytometric studies were performed on archival stage O (Ta) papillary grades 1 to 2 transitional cell carcinomas of the bladder to learn whether deoxyribonucleic acid histogram patterns predict disease recurrence and progression. All patients with aneuploid histograms as predicted experienced recurrent disease. In 20 of 28 cases of recurrent disease the ploidy pattern changed during recurrence. Because of this finding we predicted disease progression if 2 or more histograms in the sequence were aneuploid. Two-thirds (8 of 12) of those having more than 1 aneuploid tumor incident experienced invasion, while only approximately a third (6 of 16) lacking repetitive aneuploidy had invasion. Furthermore, of the patients with 2 aneuploid lesions half had progression within 1 year and two-thirds within 2 years after the second aneuploid lesion. Therefore, it appears that in this disease deoxyribonucleic acid histograms can provide prognostic information beyond that obtained from tumor grade and stage.
对存档的膀胱O期（Ta）1至2级乳头状移行细胞癌进行了两项盲法回顾性流式细胞术研究，以了解脱氧核糖核酸直方图模式是否能预测疾病复发和进展。所有预测为非整倍体直方图的患者均出现疾病复发。在28例复发病例中，有20例在复发期间倍性模式发生了变化。基于这一发现，如果序列中有2个或更多直方图为非整倍体，我们就预测疾病会进展。有超过1次非整倍体肿瘤事件的患者中有三分之二（12例中的8例）发生了浸润，而只有大约三分之一（16例中的6例）没有重复性非整倍体的患者发生了浸润。此外，有2个非整倍体病变的患者中，一半在第二个非整倍体病变后1年内发生了进展，三分之二在2年内发生了进展。因此，在这种疾病中，脱氧核糖核酸直方图似乎可以提供超出肿瘤分级和分期所获得的预后信息。
