Universidade Federal do Rio de Janeiro (UFRJ)- Faculdade de Farmacia- Av, Brigadeiro Trompowsky, s/n. CEP Rio de Janeiro - RJ, 21941-901, Brazil.
Curr Drug Targets. 2021;22(10):1090-1107. doi: 10.2174/1389450122999210101230743.
Photodynamic Therapy (PDT) is a therapeutic modality used for several malignant and premalignant skin disorders, including Bowen's disease skin cancers and Superficial Basal Cell Carcinoma (BCC). Several photosensitizers (PSs) have been explored for tumor destruction of skin cancers, after their activation by a light source of appropriate wavelength. Topical release of PSs avoids prolonged photosensitization reactions associated with systemic administration; however, its clinical usefulness is influenced by its poor tissue penetration and the stability of the active agent. Nanotechnology-based drug delivery systems are promising tool to enhance the efficiency for PDT of cancer. This review focuses on PSs encapsulated in nanocarriers explored for PDT of skin tumors.
光动力疗法（PDT）是一种用于多种恶性和癌前皮肤疾病的治疗方式，包括 Bowen 病皮肤癌和浅表基底细胞癌（BCC）。已经探索了几种光敏剂（PS）用于通过适当波长的光源激活后破坏皮肤癌肿瘤。与全身给药相关的长时间光敏化反应相比，局部释放 PS 可以避免这种情况；但是，其临床应用受到其组织穿透性差和活性药物的稳定性的影响。基于纳米技术的药物递送系统是提高癌症 PDT 效率的有前途的工具。本综述重点介绍了封装在纳米载体中的 PS，用于治疗皮肤肿瘤的 PDT。
