Szeimies R M, Landthaler M
Klinik und Poliklinik für Dermatologie, Universität, Regensburg.
Hautarzt. 1995 May;46(5):315-8. doi: 10.1007/s001050050258.
Photodynamic therapy (PDT) is an experimental treatment modality which is based on photochemical destruction of tumour tissue by means of different sensitizers and irradiation with red light. The greatest disadvantage of systemic administration of photosensitizers (mostly porphyrins) is cutaneous photosensitization of the patient, which lasts for some months. An alternative therapeutic technique for superficial skin tumours is the topical application of sensitizers, especially 5-aminolevulinic acid (ALA). Therapeutic selectivity derives from enhanced ALA penetration across abnormal parakeratotic stratum corneum and from preferential accumulation of bioconverted protoporphyrin IX, which serves as photosensitizer in cells of epithelial origin. Two patients suffering from different epithelial tumours (superficial basal cell carcinoma, Bowen's disease) and treated with topical PDT after ALA application are reported. Both tumours showed complete remission, and up to 12 months after treatment there were no clinical or histological signs of tumour recurrence. Cosmetic results were good.
光动力疗法（PDT）是一种实验性治疗方式，它基于利用不同的光敏剂和红光照射对肿瘤组织进行光化学破坏。全身给药光敏剂（主要是卟啉）的最大缺点是患者会出现皮肤光敏反应，这种反应会持续数月。对于浅表性皮肤肿瘤，一种替代治疗技术是局部应用光敏剂，尤其是5-氨基酮戊酸（ALA）。治疗的选择性源于ALA穿过异常不全角化角质层的渗透性增强，以及生物转化的原卟啉IX的优先积累，原卟啉IX在上皮来源的细胞中作为光敏剂发挥作用。本文报道了两名患有不同上皮肿瘤（浅表基底细胞癌、鲍温病）的患者，在应用ALA后接受了局部光动力疗法治疗。两种肿瘤均显示完全缓解，并且在治疗后长达12个月没有肿瘤复发的临床或组织学迹象。美容效果良好。
