Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, India.
Shri Baba Mastnath Institute of Pharmaceutical Sciences and Research, Baba Mastnath University, Rohtak-124001, India.
Recent Adv Drug Deliv Formul. 2021;15(1):3-14. doi: 10.2174/1872211314999210104211125.
There is no single-component excipient that fulfills all the requisite performance to allow an active pharmaceutical ingredient to be formulated into a specific dosage form. Co-processing is a novel concept that incorporates a combination of two or more excipients, that is advantageous and cannot be achieved using a physical admixture.
This review provides an overview of co-processed excipients, recent patents granted and filed in this field and the commercial patented technology platforms based on these excipients.
Various online patent databases were used for collecting the information on recent patents and patented co-processed excipient technologies. The recent patents such as single-step coprocessing by dry coating, novel co-processed excipients for oily drugs and novel silica-coated compositions have been discussed.
Co-processed excipients are evolving as a current and future trend of excipient technology in pharmaceutical manufacturing, which is evident by the increasing number of patents based on these excipients. Among various techniques, the maximum number of patents is based on the spray drying technique.
In this work, the authors have focussed on recent patents and commercial technologies on co-processed excipient. A better understanding of this will help researchers and pharmaceutical industries to select the appropriate platform, or to develop new innovative co-processed excipients with improved tableting characteristics.
目前还没有一种单一的辅料能够完全满足特定剂型药物制剂的所有性能要求。共处理是一种新的概念，它将两种或两种以上的辅料结合在一起，具有优势，并且不能通过物理混合物来实现。
本文综述了共处理辅料、该领域最近获得和提交的专利，以及基于这些辅料的商业化专利技术平台。
利用各种在线专利数据库收集了关于最近专利和专利共处理辅料技术的信息。讨论了最近的专利，如通过干涂层一步共处理、油性药物的新型共处理辅料和新型硅涂层组合物。
共处理辅料作为药物制剂辅料技术的当前和未来趋势正在发展，这从基于这些辅料的专利数量不断增加就可以看出。在各种技术中，基于喷雾干燥技术的专利数量最多。
在这项工作中，作者重点关注了共处理辅料的最新专利和商业技术。更好地了解这一点将有助于研究人员和制药行业选择合适的平台，或开发具有改善压片特性的新型创新共处理辅料。
