J Biomed Nanotechnol. 2020 Aug 1;16(8):1196-1204. doi: 10.1166/jbn.2020.2965.
Cancer vaccine is well recognized as a novel but effective way for cancer immunotherapy. Especially, the role of dendritic cells (DCs) in antigen presentation properties is critical for the final performance of cancer vaccine. Herein, a lipid (Li) coated calcium carbonate (CC) vehicle (Li/CC) was employed to load chlorin e6 (Ce6) to serve as a potential vaccine (Li/CC-Ce6) for effective immunotherapy of colorectal cancer. It was suggested that the loaded Ce6 within Li/CCCe6 can be activated under laser irradiation. The photodynamic therapy (PDT) of Ce6 was expected to produce reactive oxygen species (ROS) to cause cell death and expose tumor-associated antigen (TAA). In addition, the produced ROS can mimic the inflammatory responses for the recruitment of DC to initiate strong immune response cascade. Moreover, the recruitment of DC can recognize the exposed TAA to stimulate DC for effective vaccination . Results from and assays demonstrated the strong ability of this platform to enhance DC vaccination, resulting in promising growth inhibition of both primary and distant tumors.
癌症疫苗被公认为癌症免疫疗法的一种新颖而有效的方法。特别是树突状细胞 (DCs) 在抗原呈递特性方面的作用对于癌症疫苗的最终效果至关重要。在此，采用脂质 (Li) 包覆碳酸钙 (CC) 载体 (Li/CC) 负载氯乙酮 (Ce6) 作为一种有效的结直肠癌免疫治疗的潜在疫苗 (Li/CC-Ce6)。有研究表明，Li/CC-Ce6 中负载的 Ce6 在激光照射下可以被激活。Ce6 的光动力疗法 (PDT) 有望产生活性氧 (ROS) 以引起细胞死亡并暴露肿瘤相关抗原 (TAA)。此外，产生的 ROS 可以模拟炎症反应，招募树突状细胞 (DC) 以引发强烈的免疫反应级联。此外，DC 的募集可以识别暴露的 TAA，刺激 DC 进行有效接种。和 试验的结果表明，该平台具有增强 DC 疫苗接种的强大能力，从而对原发性和远处肿瘤的生长抑制具有良好的抑制作用。
