在新冠疫情时代，是否需要重新考虑在异基因造血细胞移植后使用 G-CSF？
Time to revisit the use of G-CSF after allogeneic haematopoietic cell transplantation in COVID-19 era?
机构信息
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX, 77030, USA.
出版信息
Br J Cancer. 2021 Mar;124(7):1183. doi: 10.1038/s41416-020-01195-8. Epub 2021 Jan 4.
Abstract
The use of granulocyte colony-stimulating factor (G-CSF) in patients with haematological malignancies is associated with less febrile neutropenia episodes. But in the presence of COVID-19 infection, the administration of G-CSF is challenging as it may trigger a robust inflammatory reaction resulting in cytokine storm, respiratory failure and severe outcomes.
摘要
在血液恶性肿瘤患者中使用粒细胞集落刺激因子（G-CSF）可减少发热性中性粒细胞减少症的发生。但是，在 COVID-19 感染的情况下，G-CSF 的给药具有挑战性，因为它可能引发强烈的炎症反应，导致细胞因子风暴、呼吸衰竭和严重后果。
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