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病例报告:在自体造血干细胞移植背景下COVID-19的成功转归:抗SARS-CoV-2疫苗和早期瑞德西韦的影响

Case report: Successful outcome of COVID-19 in the context of autologous hematopoietic stem cell transplantation: The impact of the anti-SARS-CoV-2 vaccine and early remdesivir.

作者信息

Lasagna Angioletta, Piralla Antonio, Secondino Simona, Sacchi Paolo, Baldanti Fausto, Bruno Raffaele, Pedrazzoli Paolo

机构信息

Medical Oncology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

出版信息

Front Med (Lausanne). 2022 Jul 22;9:944855. doi: 10.3389/fmed.2022.944855. eCollection 2022.

Abstract

Coronavirus disease (COVID-19) in patients undergoing hematopoietic stem cell transplantation (HSCT) is a major issue. None of the published papers have reported data on the outcome of HSCT patients with COVID-19 according to the vaccination status and the short course of remdesivir (RDV). Therefore, we present the case of a 22-year-old man with relapsed testicular non-seminomatous germ-cell tumor who was diagnosed with COVID-19 during his first auto-HSCT. Our case report is the first one describing the efficacy of early RDV (and its anti-inflammatory effects that might counterbalance the negative effect of the recombinant human granulocyte-colony stimulating factors -rhG-CSF-) in the context of severe neutropenia following HSCT with the concomitant onset of COVID-19.

摘要

造血干细胞移植(HSCT)患者的冠状病毒病(COVID-19)是一个重大问题。已发表的论文均未报告根据疫苗接种状况和瑞德西韦(RDV)短疗程治疗的COVID-19造血干细胞移植患者的结局数据。因此,我们报告了一例22岁复发性睾丸非精原细胞瘤生殖细胞肿瘤男性患者,其在首次自体造血干细胞移植期间被诊断为COVID-19。我们的病例报告是首例描述早期瑞德西韦疗效(及其抗炎作用,可能抵消重组人粒细胞集落刺激因子-rhG-CSF-的负面影响)的报告,该病例是在造血干细胞移植后严重中性粒细胞减少并伴有COVID-19发病的情况下。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f16/9353116/d48f8d5267de/fmed-09-944855-g0001.jpg

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