Hommerding Oliver, Allory Yves, Argani Pedram, Bismar Tarek A, Bubendorf Lukas, Canete-Portillo Sofía, Chaux Alcides, Chen Ying-Bei, Cheng Liang, Cubilla Antonio L, Egevad Lars, Gill Anthony J, Grignon David J, Hartmann Arndt, Hes Ondrej, Idrees Muhammad T, Kao Chia-Sui, Knowles Margaret A, Looijenga Leendert H J, Lotan Tamara L, Pritchard Colin C, Rubin Mark A, Tomlins Scott A, Van der Kwast Theodorus H, Velazquez Elsa F, Warrick Joshua I, Williamson Sean R, Kristiansen Glen
Institut für Pathologie, Universitätsklinikum Bonn, Venusberg-Campus 1, Gebäude 62, 53127, Bonn, Deutschland.
Department of Pathology, Institut Curie, Saint-Cloud, Frankreich.
Pathologe. 2021 May;42(3):310-318. doi: 10.1007/s00292-020-00888-4. Epub 2021 Jan 4.
Comprehensive understanding of molecular principles in cancer and the diversification of oncological therapy promise individual therapeutic concepts, which have not yet found their way into urogenital cancer therapy. In March 2019 the International Society of Urogenital Pathology (ISUP) therefore held a consensus conference on recommendations for molecular diagnostics of genitourinary tumors, which were published in five separate manuscripts and are summarized in this article.In preparation for the conference, a comprehensive survey of current practices for molecular testing of urogenital tumors was carried out by members of the ISUP. At the conference, the results and the corresponding background information were presented by five working groups and recommendations for action for diagnostics were developed. An agreement between 66% of the conference participants was defined as consensus.
全面理解癌症的分子原理以及肿瘤治疗方法的多样化有望实现个性化治疗理念，但这些理念尚未应用于泌尿生殖系统癌症的治疗。因此，2019年3月，国际泌尿生殖病理学会（ISUP）召开了一次关于泌尿生殖系统肿瘤分子诊断建议的共识会议，相关内容发表在五篇独立的手稿中，并在本文中进行了总结。在会议筹备过程中，ISUP成员对泌尿生殖系统肿瘤分子检测的当前实践进行了全面调查。会议上，五个工作组介绍了调查结果及相应的背景信息，并制定了诊断行动建议。66%的与会者达成的一致意见被定义为共识。
