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肌肉减少症作为早期卵巢癌预后的预测指标。

Sarcopenia as a Predictor of Prognosis in Early Stage Ovarian Cancer.

机构信息

Department of Obstetrics and Gynecology, Konkuk Medical Center, Konkuk University School of Medicine, Seoul, Korea.

Department of Obstetrics and Gynecology, Korea University Anam Medical Center, Korea University College of Medicine, Seoul, Korea.

出版信息

J Korean Med Sci. 2021 Jan 4;36(1):e2. doi: 10.3346/jkms.2021.36.e2.

DOI:10.3346/jkms.2021.36.e2
PMID:33398939
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7781849/
Abstract

BACKGROUND

To identify sarcopenia as a predictive prognostic factor of ovarian cancer in terms of survival outcome in patients with early-stage ovarian cancer.

METHODS

Data of Konkuk University Medical Center from March 2002 to December 2017 were reviewed retrospectively. Eighty-two patients who underwent surgery due to early-stage (International Federation of Gynecology and Obstetrics stage I/II) ovarian cancer and had computed tomography (CT) images taken at the initial diagnosis were included. The initial CT scan images were analyzed with SliceOmatic software (TomoVision). A sarcopenia cutoff value was defined as a skeletal muscle index of ≤ 38.7 cm²/m². Overall survival (OS) times were compared according to the existence of sarcopenia, and subgroup analyses were performed.

RESULTS

A Kaplan-Meier analysis showed a significant survival disadvantage for patients with early-stage ovarian cancer when they had sarcopenia ( < 0.001; log-rank test). Sarcopenia remained a significant prognostic factor for OS in early-stage ovarian cancer, in a Cox proportional hazards model regression analysis (HR, 21.9; 95% CI, 2.0-199.9; = 0.006).

CONCLUSION

This study demonstrated that sarcopenia was predictive of OS in patients with early-stage ovarian cancer. Further prospective studies with a larger number of patients are warranted to determine the extent to which sarcopenia can be used as a prognostic factor in ovarian cancer.

摘要

背景

确定骨骼肌减少症作为早期卵巢癌患者生存结局的预测预后因素。

方法

回顾性分析 2002 年 3 月至 2017 年 12 月期间韩国孔敬大学医学中心的数据。纳入了 82 例因早期（国际妇产科联合会分期 I/II 期）卵巢癌接受手术且在初诊时进行了计算机断层扫描（CT）检查的患者。使用 SliceOmatic 软件（TomoVision）对初始 CT 扫描图像进行分析。将骨骼肌指数≤38.7cm²/m²定义为骨骼肌减少症的截断值。根据是否存在骨骼肌减少症比较总生存（OS）时间，并进行亚组分析。

结果

Kaplan-Meier 分析显示，早期卵巢癌患者存在骨骼肌减少症时生存明显不利（<0.001；log-rank 检验）。在 Cox 比例风险回归分析中，骨骼肌减少症仍然是早期卵巢癌 OS 的显著预后因素（HR，21.9；95%CI，2.0-199.9；=0.006）。

结论

本研究表明，骨骼肌减少症可预测早期卵巢癌患者的 OS。需要进一步进行前瞻性研究，纳入更多患者，以确定骨骼肌减少症在卵巢癌中的预后价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e91f/7781849/774801b0058a/jkms-36-e2-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e91f/7781849/f3a0509e60c0/jkms-36-e2-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e91f/7781849/4387d35748b6/jkms-36-e2-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e91f/7781849/774801b0058a/jkms-36-e2-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e91f/7781849/f3a0509e60c0/jkms-36-e2-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e91f/7781849/4387d35748b6/jkms-36-e2-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e91f/7781849/774801b0058a/jkms-36-e2-g003.jpg

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Sarcopenia and ovarian cancer survival: a systematic review and meta-analysis.肌肉减少症与卵巢癌生存：系统评价和荟萃分析。
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