Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.
Department of Clinical Pathology, School of Medicine, Kyungpook National University, Daegu, Korea.
J Korean Med Sci. 2021 Jan 4;36(1):e10. doi: 10.3346/jkms.2021.36.e10.
The cause of epithelioid granulomatous inflammation varies widely depending on the affected organ, geographic region, and whether the granulomas morphologically contain necrosis. Compared with other organs, the etiological distribution and morphological patterns of pleural epithelioid granulomas have rarely been investigated. We evaluated the final etiologies and morphological patterns of pleural epithelioid granulomatous inflammation in a tuberculosis (TB)-prevalent country. Of 83 patients with pleural granulomas, 50 (60.2%) had confirmed TB pleurisy (TB-P) and 29 (34.9%) had probable TB-P. Four patients (4.8%) with non-TB-P were diagnosed. With the exception of microbiological results, there was no significant difference in clinical characteristics and granuloma patterns between the confirmed TB-P and non-TB-P groups, or between patients with confirmed and probable TB-Ps. These findings suggest that most pleural granulomatous inflammation (95.2%) was attributable to TB-P in TB-endemic areas and that the granuloma patterns contributed little to the prediction of final diagnosis compared with other organs.
根据受累器官、地理位置以及肉芽肿是否在形态上存在坏死的情况，上皮样肉芽肿性炎症的病因差异很大。与其他器官相比，胸膜上皮样肉芽肿的病因分布和形态模式很少被研究。我们评估了一个结核病高发国家胸膜上皮样肉芽肿性炎症的最终病因和形态模式。在 83 例胸膜肉芽肿患者中，50 例（60.2%）有明确的结核性胸膜炎（TB-P），29 例（34.9%）有疑似 TB-P。4 例（4.8%）为非 TB-P。除微生物学结果外，确诊 TB-P 与非 TB-P 组、确诊与疑似 TB-P 组之间在临床特征和肉芽肿模式方面均无显著差异。这些发现表明，在结核病流行地区，大多数胸膜肉芽肿性炎症（95.2%）归因于 TB-P，与其他器官相比，肉芽肿模式对最终诊断的预测作用较小。
