使用超短回波时间 MRI 对兔模型声门下狭窄进行定量评估。
Quantitative Evaluation of Subglottic Stenosis Using Ultrashort Echo Time MRI in a Rabbit Model.
机构信息
Center for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, U.S.A.
Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, U.S.A.
出版信息
Laryngoscope. 2021 Jun;131(6):E1971-E1979. doi: 10.1002/lary.29363. Epub 2021 Jan 5.
OBJECTIVE/HYPOTHESIS: To assess the ability of ultra-short echo time (UTE)-MRI to detect subglottic stenosis (SGS) and evaluate response to balloon dilation. To correlate measurements from UTE-MRI with endotracheal-tube (ETT)-sizing and to investigate whether SGS causes change in airway dynamics.
STUDY DESIGN
Animal research study.
METHODS
Eight adult New-Zealand white rabbits were used as they approximate neonatal airway-size. The airways were measured using ETT-sizing and 3D UTE-MRI at baseline, 2 weeks post-cauterization induced SGS injury, and post-balloon dilation treatment. UTE-MR images were acquired to determine airway anatomy and motion. Airways were segmented from MR images. Cross-sectional area (CSA), major and minor diameters (D and D ), and eccentricity were measured.
RESULTS
Post-injury CSA at SGS was significantly reduced (mean 38%) compared to baseline (P = .003) using UTE-MRI. ETT-sizing correlated significantly with MRI-measured CSA at the SGS location (r = 0.6; P < .01), particularly at the post-injury timepoint (r = 0.93; P < .01). Outer diameter from ETT-sizing (OD) correlated significantly with D (r = 0.63; P < .01) from UTE-MRI at the SGS location, especially for the post-injury timepoint (r = 0.91; P < .01). Mean CSA of upper trachea did not change significantly between end-expiration and end-inspiration at any timepoint (all P > .05). Eccentricity of the upper trachea increased significantly post-balloon dilation (P < .05).
CONCLUSIONS
UTE-MRI successfully detected SGS and treatment response in the rabbit model, with good correlation to ETT-sizing. Balloon dilation increased CSA at SGS, but not to baseline values. SGS did not alter dynamic motion for the trachea in this rabbit model; however, tracheas were significantly eccentric post-balloon dilation. UTE-MRI can detect SGS without sedation or ionizing radiation and may be a non-invasive alternative to ETT-sizing.
LEVEL OF EVIDENCE
NA Laryngoscope, 131:E1971-E1979, 2021.
目的/假设：评估超短回波时间（UTE）-MRI 检测声门下狭窄（SGS）和评估球囊扩张反应的能力。将 UTE-MRI 测量值与气管内管（ETT）尺寸相关联，并研究 SGS 是否导致气道动力学变化。
研究设计
动物研究。
方法
使用 8 只成年新西兰白兔，因为它们近似于新生儿气道大小。在基线、SGS 损伤后 2 周和球囊扩张治疗后，使用 ETT 尺寸和 3D UTE-MRI 测量气道。采集 UTE-MR 图像以确定气道解剖结构和运动。从 MR 图像中分割气道。测量横截面积（CSA）、主直径（D）和次直径（D）以及偏心率。
结果
使用 UTE-MRI，SGS 损伤后 CSA 明显减少（平均减少 38%）（P =.003）。ETT 尺寸与 SGS 位置的 MRI 测量 CSA 显著相关（r = 0.6；P < .01），尤其是在损伤后时间点（r = 0.93；P < .01）。ETT 尺寸的外径（OD）与 SGS 位置的 UTE-MRI 的 D （r = 0.63；P < .01）显著相关，尤其是在损伤后时间点（r = 0.91；P < .01）。在任何时间点，呼气末和吸气末之间的上气管的平均 CSA 均无明显变化（均 P > .05）。球囊扩张后 SGS 的偏心度显著增加（P < .05）。
结论
UTE-MRI 成功地在兔模型中检测到 SGS 和治疗反应，与 ETT 尺寸具有良好的相关性。球囊扩张增加了 SGS 的 CSA，但未达到基线值。在这个兔模型中，SGS 并没有改变气管的动态运动；然而，球囊扩张后气管明显偏心。UTE-MRI 可以在没有镇静或电离辐射的情况下检测到 SGS，并且可能是 ETT 尺寸的替代方法。
证据水平
无喉镜，131：E1971-E1979，2021。
Zotero 插件