Rafic Hariri School of Nursing.
Department of Pharmacology and Toxicology, American University of Beirut, Beirut, Lebanon.
J Hypertens. 2021 May 1;39(5):830-845. doi: 10.1097/HJH.0000000000002733.
Blood pressure (BP) varies on the long, short and very-short term. Owing to the hidden physiological and pathological information present in BP time-series, increasing interest has been given to the study of continuous, beat-to-beat BP variability (BPV) using invasive and noninvasive methods. Different linear and nonlinear parameters of variability are employed in the characterization of BP signals in health and disease. Although linear parameters of beat-to-beat BPV are mainly measures of dispersion, such as standard deviation (SD), nonlinear parameters of BPV quantify the degree of complexity/irregularity- using measures of entropy or self-similarity/correlation. In this review, we summarize the value of linear and nonlinear parameters in reflecting different information about the pathophysiology of changes in beat-to-beat BPV independent of or superior to mean BP. We then provide a comparison of the relative power of linear and nonlinear parameters of beat-to-beat BPV in detecting early and subtle differences in various states. The practical advantage and utility of beat-to-beat BPV monitoring support its incorporation into routine clinical practices.
血压（BP）在长、短和极短时间内都存在变化。由于 BP 时间序列中存在隐藏的生理和病理信息，使用侵入性和非侵入性方法对连续、逐拍 BP 变异性（BPV）的研究引起了越来越多的关注。在健康和疾病中，不同的线性和非线性变异性参数被用于描述 BP 信号。尽管逐拍 BPV 的线性参数主要是离散度的度量，如标准差（SD），但 BPV 的非线性参数则使用熵或自相似性/相关性的度量来量化复杂性/不规则性的程度。在这篇综述中，我们总结了线性和非线性参数在反映逐拍 BPV 变化的病理生理学方面的不同信息的价值，这些信息独立于或优于平均 BP。然后，我们比较了线性和非线性参数在检测各种状态下早期和微妙差异的相对能力。逐拍 BPV 监测的实际优势和实用性支持将其纳入常规临床实践。
