Division of Cardiology, Department of Internal Medicine, College of Medicine, Hanyang University, Seoul.
Division of Cardiology, Korea University Ansan Hospital, Ansan.
J Hypertens. 2021 Jun 1;39(6):1203-1209. doi: 10.1097/HJH.0000000000002753.
Hand grip strength (HGS) has been associated with cardiovascular events. However, the exact mechanism responsible for the inverse association between HGS and cardiovascular events has not been established. The aim of this study was to assess whether arterial stiffness mediates this association.
We studied 1508 participants (age; 60 ± 5, men; 47.5%) from the Ansan cohort of the Korean Genome Epidemiology Study. Participants were assessed for various parameters of arterial stiffness as well as HGS. The augmentation index (AIx) and brachial-ankle pulse wave velocity (baPWV) were evaluated by using an applanation tonometer and automated waveform analyzer, respectively. Carotid intima medial thickness (IMT) was measured by B-mode ultrasonogram with a 7.5-MHz linear array transducer. HGS was evaluated using a Jamar dynamometer.
With increased grip strength, AIx decreased (r = 0.437, P < 0.001). baPWV (r = 0.044, P = 0.107) and carotid IMT (r = 0.005, P = 0.856) had no significant correlation with grip strength. This trend was consistently observed regardless of hypertension, but was more pronounced in participants with hypertension.
HGS was significantly correlated with AIx, but not with baPWV and carotid IMT. Our findings suggest that central arterial stiffness could mediate the association between HGS and cardiovascular events.
手握力（HGS）与心血管事件有关。然而，导致 HGS 与心血管事件呈负相关的确切机制尚未确定。本研究旨在评估动脉僵硬度是否介导这种关联。
我们研究了来自韩国基因组流行病学研究安山队列的 1508 名参与者（年龄 60±5 岁，男性 47.5%）。评估了参与者的各种动脉僵硬度参数以及 HGS。通过平板式血压计和自动波形分析仪分别评估了增强指数（AIx）和肱踝脉搏波速度（baPWV）。颈动脉内膜中层厚度（IMT）通过 B 型超声仪用 7.5MHz 线性阵列探头进行测量。使用 Jamar 握力计评估 HGS。
随着握力的增加，AIx 降低（r=0.437，P<0.001）。baPWV（r=0.044，P=0.107）和颈动脉 IMT（r=0.005，P=0.856）与握力无显著相关性。这种趋势无论是否存在高血压均一致观察到，但在高血压患者中更为明显。
HGS 与 AIx 显著相关，而与 baPWV 和颈动脉 IMT 无关。我们的研究结果表明，中心动脉僵硬度可能介导 HGS 与心血管事件之间的关联。
