Department of Cell and Molecular Medicine; and.
Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL.
J Acquir Immune Defic Syndr. 2021 Apr 15;86(5):e139-e145. doi: 10.1097/QAI.0000000000002617.
Bone mineral density loss and fat accumulation are common in people living with HIV. The bone-derived hormone, undercarboxylated osteocalcin (ucOCN) regulates fat metabolism. We investigated the relationship between ucOCN change and body fat change among perimenopausal/postmenopausal HIV-seronegative and HIV-seropositive women on long-term antiretrovirals.
Perimenopausal and postmenopausal women enrolled in the Women's Interagency HIV Study MSK substudy underwent trunk and total fat assessment by dual energy x-ray absorptiometry (DXA) at study enrollment (index visit) and again 2 years later. Circulating ucOCN and cOCN were also measured at the index and 2-year visits. The correlation between the 2-year change in ucOCN and cOCN and change in trunk and total fat was assessed as a function of HIV serostatus using linear regression modeling. Multivariate linear regression assessed the association between ucOCN and cOCN change and total and trunk fat change after adjusting for sociodemographic variables. Linear regression models restricted to HIV-seropositive women were performed to examine the contributions of HIV-specific factors (index CD4 count, viral load, and combined antiretroviral therapy use) on the associations.
Increased ucOCN over the 2-year follow-up was associated with less trunk and total fat accumulation in models adjusting for HIV serostatus and participants sociodemographics, whereas there was no association with cOCN and the fat parameters. None of the HIV-specific factors evaluated influenced the association between ucOCN and fat parameters.
The current study suggests that increases in ucOCN are associated with decreased fat accumulation in HIV-seronegative and HIV-seropositive postmenopausal women on long-term antiretroviral therapy.
骨质密度流失和脂肪堆积在 HIV 感染者中很常见。骨源激素，非羧化骨钙素（ucOCN）调节脂肪代谢。我们研究了绝经前后 HIV 阴性和 HIV 阳性长期接受抗逆转录病毒治疗的女性中，ucOCN 变化与体脂变化之间的关系。
参加妇女艾滋病研究机构（Women's Interagency HIV Study）MSK 子研究的绝经前后女性在研究入组（索引访视）和 2 年后再次接受双能 X 线吸收法（DXA）进行躯干和总脂肪评估。在索引和 2 年访视时还测量了循环 ucOCN 和 cOCN。使用线性回归模型，根据 HIV 血清状况评估了 2 年内 ucOCN 和 cOCN 变化与躯干和总脂肪变化之间的相关性。多元线性回归评估了在调整社会人口统计学变量后，ucOCN 和 cOCN 变化与总脂肪和躯干脂肪变化之间的关联。对 HIV 血清阳性女性进行线性回归模型，以检查 HIV 特异性因素（索引 CD4 计数、病毒载量和联合抗逆转录病毒治疗的使用）对关联的影响。
在调整了 HIV 血清状况和参与者社会人口统计学的模型中，2 年随访期间 ucOCN 的增加与躯干和总脂肪积累的减少相关，而与 cOCN 和脂肪参数无关联。评估的 HIV 特异性因素均未影响 ucOCN 与脂肪参数之间的关联。
目前的研究表明，ucOCN 的增加与长期接受抗逆转录病毒治疗的 HIV 阴性和 HIV 阳性绝经后女性的脂肪积累减少有关。
