Nazar Gabriela, Ulloa Natalia, Martínez-Sanguinetti María Adela, Leiva Ana María, Petermann-Rocha Fanny, Martínez Ximena Díaz, Lanuza Fabian, Cigarroa Igor, Concha-Cisternas Yeny, Troncoso Claudia, Mardones Lorena, Villagrán Marcelo, Celis-Morales Carlos
Departamento de Psicología y Centro Vida Saludable de la Universidad de Concepción, Universidad de Concepción, Concepción, Chile.
Departamento de Bioquímica Clínica e Inmunología, Facultad de Farmacia y Centro de Vida Saludable, Universidad de Concepción, Concepción, Chile.
Rev Med Chil. 2020 Jul;148(7):947-955. doi: 10.4067/S0034-98872020000700947.
Depression has been previously associated with cognitive impairment in high income country populations. However, its association in the Chilean population has not been investigated.
To investigate the association between depression and cognitive impairment.
Data from 1384 Chilean adults aged > 60 years, participating in the National Health Survey 2009-2010 was analyzed. Cognitive impairment was assessed using the Mini Mental Examination score. The medical diagnosis of depression was self-reported. The association between depression and cognitive impairment was assessed using a logistic regression.
Depression was positively associated with cognitive impairment. However, the magnitude of the association was higher in men (Odds ratio (OR) = 4.02 [95% confidence intervals (CI): 1.44; 6.61], p < 0.01]) than in women (OR = 2.23 [95%CI: 1.03; 3.43], p = 0.04). Older adults who were diagnosed for the first time with depression after 65 years of age, showed a stronger association with cognitive impairment (OR = 6.65 [95% CI: 2.39; 10.9], p < 0.01) than those diagnosed before 55 years.
Our study confirms the association between depression and cognitive impairment. Further research is needed to elucidate the nature and potential mechanisms that link depression with cognitive impairment.
抑郁症先前已被证明与高收入国家人群的认知障碍有关。然而，其在智利人群中的关联尚未得到研究。
研究抑郁症与认知障碍之间的关联。
分析了参与2009 - 2010年全国健康调查的1384名年龄大于60岁的智利成年人的数据。使用简易精神状态检查评分评估认知障碍。抑郁症的医学诊断通过自我报告获得。使用逻辑回归评估抑郁症与认知障碍之间的关联。
抑郁症与认知障碍呈正相关。然而，男性的关联程度更高（优势比（OR）= 4.02 [95%置信区间（CI）：1.44；6.61]，p < 0.01），而女性为（OR = 2.23 [95%CI：1.03；3.43]，p = 0.04）。65岁后首次被诊断为抑郁症的老年人与认知障碍的关联更强（OR = 6.65 [95%CI：2.39；10.9]，p < 0.01），比55岁之前被诊断的人。
我们的研究证实了抑郁症与认知障碍之间的关联。需要进一步研究以阐明将抑郁症与认知障碍联系起来的性质和潜在机制。
